Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA061321-03
Application #
2102069
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1994-05-01
Project End
1997-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Rosalind Franklin University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
069501252
City
North Chicago
State
IL
Country
United States
Zip Code
60064
Ghoshal, K; Majumder, S; Li, Z et al. (2000) Suppression of metallothionein gene expression in a rat hepatoma because of promoter-specific DNA methylation. J Biol Chem 275:539-47
Ghoshal, K; Majumder, S; Li, Z et al. (1999) Transcriptional induction of metallothionein-I and -II genes in the livers of Cu,Zn-superoxide dismutase knockout mice. Biochem Biophys Res Commun 264:735-42
Majumder, S; Ghoshal, K; Li, Z et al. (1999) Hypermethylation of metallothionein-I promoter and suppression of its induction in cell lines overexpressing the large subunit of Ku protein. J Biol Chem 274:28584-9
Jacob, S T; Ghoshal, K; Sheridan, J F (1999) Induction of metallothionein by stress and its molecular mechanisms. Gene Expr 7:301-10
Majumder, S; Ghoshal, K; Li, Z et al. (1999) Silencing of metallothionein-I gene in mouse lymphosarcoma cells by methylation. Oncogene 18:6287-95
Ghoshal, K; Wang, Y; Sheridan, J F et al. (1998) Metallothionein induction in response to restraint stress. Transcriptional control, adaptation to stress, and role of glucocorticoid. J Biol Chem 273:27904-10
Aniskovitch, L P; Jacob, S T (1998) Distinct rat proteins can recognize CCAAT-homologous sequences of the metallothionein promoter and trans-activate this promoter. Oncogene 16:1475-86
Ghoshal, K; Li, Z; Jacob, S T (1998) Overexpression of the large subunit of the protein Ku suppresses metallothionein-I induction by heavy metals. Proc Natl Acad Sci U S A 95:10390-5
Aniskovitch, L P; Jacob, S T (1997) Purification and characterization of a rat liver protein that recognizes CCAAT-homologous sequences of the metallothionein promoter and trans-activates this promoter. Arch Biochem Biophys 341:337-46
Datta, P K; Jacob, S T (1997) Activation of the metallothionein-I gene promoter in response to cadmium and USF in vitro. Biochem Biophys Res Commun 230:159-63

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