Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA061586-04
Application #
2102320
Study Section
Special Emphasis Panel (SRC (57))
Project Start
1993-08-01
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1998-05-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Iwamoto, Marian; Banerjee, Debabrata; Menon, Lata G et al. (2004) Overexpression of E2F-1 in lung and liver metastases of human colon cancer is associated with gene amplification. Cancer Biol Ther 3:395-9
Bertino, Joseph R; Banerjee, Debabrata (2003) Is the measurement of thymidylate synthase to determine suitability for treatment with 5-fluoropyrimidines ready for prime time? Clin Cancer Res 9:1235-9
Mayer-Kuckuk, Philipp; Doubrovin, Mikhail; Gusani, Niraj J et al. (2003) Imaging of dihydrofolate reductase fusion gene expression in xenografts of human liver metastases of colorectal cancer in living rats. Eur J Nucl Med Mol Imaging 30:1281-91
Mayer-Kuckuk, Philipp; Banerjee, Debabrata; Malhotra, Sundeep et al. (2002) Cells exposed to antifolates show increased cellular levels of proteins fused to dihydrofolate reductase: a method to modulate gene expression. Proc Natl Acad Sci U S A 99:3400-5
Banerjee, Debabrata; Mayer-Kuckuk, Philipp; Capiaux, Gina et al. (2002) Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase. Biochim Biophys Acta 1587:164-73
Banerjee, Debabrata; Bertino, Joseph R (2002) Myeloprotection with drug-resistance genes. Lancet Oncol 3:154-8
Mayer-Kuckuk, Philipp; Banerjee, Debabrata; Kemeny, Nancy et al. (2002) Molecular therapies for colorectal cancer metastatic to the liver. Mol Ther 5:492-500
Longo, G S; Izzo, J; Gorlick, R et al. (2001) Characterization and drug sensitivity of four newly established colon adenocarcinoma cell lines to antifolate inhibitors of thymidylate synthase. Oncol Res 12:309-14
Banerjee, D; Gorlick, R; Liefshitz, A et al. (2000) Levels of E2F-1 expression are higher in lung metastasis of colon cancer as compared with hepatic metastasis and correlate with levels of thymidylate synthase. Cancer Res 60:2365-7
Gorlick, R; Bertino, J R (1999) Drug resistance in colon cancer. Semin Oncol 26:606-11

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