Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA061823-03
Application #
2102627
Study Section
Pathology B Study Section (PTHB)
Project Start
1994-01-14
Project End
1996-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
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Hepler, J R; Biddlecome, G H; Kleuss, C et al. (1996) Functional importance of the amino terminus of Gq alpha. J Biol Chem 271:496-504
Schriner, J E; Yi, W; Hofmann, S L (1996) cDNA and genomic cloning of human palmitoyl-protein thioesterase (PPT), the enzyme defective in infantile neuronal ceroid lipofuscinosis. Genomics 34:317-22
Jung, V; Chen, L; Hofmann, S L et al. (1995) Mutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block membrane attachment and palmitoylation of Ras proteins. Mol Cell Biol 15:1333-42
Lu, J Y; Hofmann, S L (1995) Depalmitoylation of CAAX motif proteins. Protein structural determinants of palmitate turnover rate. J Biol Chem 270:7251-6
Camp, L A; Hofmann, S L (1995) Assay and isolation of palmitoyl-protein thioesterase from bovine brain using palmitoylated H-Ras as substrate. Methods Enzymol 250:336-47
Camp, L A; Verkruyse, L A; Afendis, S J et al. (1994) Molecular cloning and expression of palmitoyl-protein thioesterase. J Biol Chem 269:23212-9