Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA062146-03
Application #
2103183
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1993-12-15
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Southern California
Department
Pharmacology
Type
Schools of Medicine
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Gopalakrishna, R; Gundimeda, U; Fontana, J A et al. (1999) Differential distribution of protein phosphatase 2A in human breast carcinoma cell lines and its relation to estrogen receptor status. Cancer Lett 136:143-51
Gopalakrishna, R; Gundimeda, U; Anderson, W B et al. (1999) Tumor promoter benzoyl peroxide induces sulfhydryl oxidation in protein kinase C: its reversibility is related to the cellular resistance to peroxide-induced cytotoxicity. Arch Biochem Biophys 363:246-58
Kaul, N; Gopalakrishna, R; Gundimeda, U et al. (1998) Role of protein kinase C in basal and hydrogen peroxide-stimulated NF-kappa B activation in the murine macrophage J774A.1 cell line. Arch Biochem Biophys 350:79-86
Gopalakrishna, R; Chen, Z H; Gundimeda, U (1997) Selenocompounds induce a redox modulation of protein kinase C in the cell, compartmentally independent from cytosolic glutathione: its role in inhibition of tumor promotion. Arch Biochem Biophys 348:37-48
Gopalakrishna, R; Gundimeda, U; Chen, Z H (1997) Cancer-preventive selenocompounds induce a specific redox modification of cysteine-rich regions in Ca(2+)-dependent isoenzymes of protein kinase C. Arch Biochem Biophys 348:25-36
Gundimeda, U; Chen, Z H; Gopalakrishna, R (1996) Tamoxifen modulates protein kinase C via oxidative stress in estrogen receptor-negative breast cancer cells. J Biol Chem 271:13504-14
Gopalakrishna, R; Chen, Z H; Gundimeda, U (1995) Modifications of cysteine-rich regions in protein kinase C induced by oxidant tumor promoters and enzyme-specific inhibitors. Methods Enzymol 252:132-46
Gopalakrishna, R; Chen, Z H; Gundimeda, U (1994) Tobacco smoke tumor promoters, catechol and hydroquinone, induce oxidative regulation of protein kinase C and influence invasion and metastasis of lung carcinoma cells. Proc Natl Acad Sci U S A 91:12233-7