Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA062392-03
Application #
2103593
Study Section
Reproductive Endocrinology Study Section (REN)
Project Start
1994-09-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609
Viveiros, Maria M; O'brien, Marilyn; Eppig, John J (2004) Protein kinase C activity regulates the onset of anaphase I in mouse oocytes. Biol Reprod 71:1525-32
Su, You-Qiang; Denegre, James M; Wigglesworth, Karen et al. (2003) Oocyte-dependent activation of mitogen-activated protein kinase (ERK1/2) in cumulus cells is required for the maturation of the mouse oocyte-cumulus cell complex. Dev Biol 263:126-38
Viveiros, Maria M; O'Brien, Marilyn; Wigglesworth, Karen et al. (2003) Characterization of protein kinase C-delta in mouse oocytes throughout meiotic maturation and following egg activation. Biol Reprod 69:1494-9
Su, You-Qiang; Wigglesworth, Karen; Pendola, Frank L et al. (2002) Mitogen-activated protein kinase activity in cumulus cells is essential for gonadotropin-induced oocyte meiotic resumption and cumulus expansion in the mouse. Endocrinology 143:2221-32
Matzuk, Martin M; Burns, Kathleen H; Viveiros, Maria M et al. (2002) Intercellular communication in the mammalian ovary: oocytes carry the conversation. Science 296:2178-80
Su, You-Qiang; Eppig, John J (2002) Evidence that multifunctional calcium/calmodulin-dependent protein kinase II (CaM KII) participates in the meiotic maturation of mouse oocytes. Mol Reprod Dev 61:560-9
Viveiros, M M; Hirao, Y; Eppig, J J (2001) Evidence that protein kinase C (PKC) participates in the meiosis I to meiosis II transition in mouse oocytes. Dev Biol 235:330-42
Eppig, J J; Wigglesworth, K; Hirao, Y (2000) Metaphase I arrest and spontaneous parthenogenetic activation of strain LTXBO oocytes: chimeric reaggregated ovaries establish primary lesion in oocytes. Dev Biol 224:60-8
Hirao, Y; Eppig, J J (1999) Analysis of the mechanism(s) of metaphase I-arrest in strain LT mouse oocytes: delay in the acquisition of competence to undergo the metaphase I/anaphase transition. Mol Reprod Dev 54:311-8
Handel, M A; Eppig, J J (1998) Sexual dimorphism in the regulation of mammalian meiosis. Curr Top Dev Biol 37:333-58

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