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Finer-Moore, Janet S; Lee, Tom T; Stroud, Robert M (2018) A Single Mutation Traps a Half-Sites Reactive Enzyme in Midstream, Explaining Asymmetry in Hydride Transfer. Biochemistry 57:2786-2795
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Keatinge-Clay, Adrian (2008) Crystal structure of the erythromycin polyketide synthase dehydratase. J Mol Biol 384:941-53
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Keatinge-Clay, Adrian T (2007) A tylosin ketoreductase reveals how chirality is determined in polyketides. Chem Biol 14:898-908
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Newby, Zachary; Lee, Tom T; Morse, Richard J et al. (2006) The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry 45:7415-28
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Keatinge-Clay, Adrian T; Stroud, Robert M (2006) The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases. Structure 14:737-48
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Finer-Moore, Janet S; Anderson, Amy C; O'Neil, Robert H et al. (2005) The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition. Acta Crystallogr D Biol Crystallogr 61:1320-34
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Keatinge-Clay, Adrian T; Maltby, David A; Medzihradszky, Katalin F et al. (2004) An antibiotic factory caught in action. Nat Struct Mol Biol 11:888-93
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Keatinge-Clay, Adrian T; Shelat, Anang A; Savage, David F et al. (2003) Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase. Structure 11:147-54
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Jez, Joseph M; Chen, Julian C-H; Rastelli, Giulio et al. (2003) Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90. Chem Biol 10:361-8
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Showing the most recent 10 out of 24 publications
