Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA063117-03
Application #
2104769
Study Section
Pathology B Study Section (PTHB)
Project Start
1994-06-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Chen, Li; Shioda, Toshi; Coser, Kathryn R et al. (2010) Genome-wide analysis of YY2 versus YY1 target genes. Nucleic Acids Res 38:4011-26
Schmidt, Emmett V; Ravitz, Michael J; Chen, Li et al. (2009) Growth controls connect: interactions between c-myc and the tuberous sclerosis complex-mTOR pathway. Cell Cycle 8:1344-51
Ravitz, Michael J; Chen, Li; Lynch, Mary et al. (2007) c-myc Repression of TSC2 contributes to control of translation initiation and Myc-induced transformation. Cancer Res 67:11209-17
Trent, Sally; Yang, Chuanwei; Li, Cuiqi et al. (2007) Heat shock protein B8, a cyclin-dependent kinase-independent cyclin D1 target gene, contributes to its effects on radiation sensitivity. Cancer Res 67:10774-81
Lynch, Mary; Chen, Li; Ravitz, Michael J et al. (2005) hnRNP K binds a core polypyrimidine element in the eukaryotic translation initiation factor 4E (eIF4E) promoter, and its regulation of eIF4E contributes to neoplastic transformation. Mol Cell Biol 25:6436-53
Lynch, Mary; Fitzgerald, Chris; Johnston, Kelly A et al. (2004) Activated eIF4E-binding protein slows G1 progression and blocks transformation by c-myc without inhibiting cell growth. J Biol Chem 279:3327-39
Schmidt, Emmett V (2004) The role of c-myc in regulation of translation initiation. Oncogene 23:3217-21
Wrobel, C; Schmidt, E V; Polymenis, M (1999) CDC64 encodes cytoplasmic alanyl-tRNA synthetase, Ala1p, of Saccharomyces cerevisiae. J Bacteriol 181:7618-20
Schmidt, E V (1999) The role of c-myc in cellular growth control. Oncogene 18:2988-96
Polymenis, M; Schmidt, E V (1999) Coordination of cell growth with cell division. Curr Opin Genet Dev 9:76-80

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