Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA063130-02
Application #
2104790
Study Section
Pathology B Study Section (PTHB)
Project Start
1995-03-22
Project End
1997-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
009214214
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Galang, Christina K; Muller, William J; Foos, Gabriele et al. (2004) Changes in the expression of many Ets family transcription factors and of potential target genes in normal mammary tissue and tumors. J Biol Chem 279:11281-92
Hever, Aniko; Oshima, Robert G; Hauser, Craig A (2003) Ets2 is not required for Ras or Neu/ErbB-2 mediated cellular transformation in vitro. Exp Cell Res 290:132-43
Foos, G; Galang, C K; Zheng, C F et al. (2001) Ras signaling to transcription activation: analysis with GAL4 fusion proteins. Methods Enzymol 333:61-73
Foos, G; Hauser, C A (2000) Altered Ets transcription factor activity in prostate tumor cells inhibits anchorage-independent growth, survival, and invasiveness. Oncogene 19:5507-16
Foos, G; Garcia-Ramirez, J J; Galang, C K et al. (1998) Elevated expression of Ets2 or distinct portions of Ets2 can reverse Ras-mediated cellular transformation. J Biol Chem 273:18871-80
McCarthy, S A; Chen, D; Yang, B S et al. (1997) Rapid phosphorylation of Ets-2 accompanies mitogen-activated protein kinase activation and the induction of heparin-binding epidermal growth factor gene expression by oncogenic Raf-1. Mol Cell Biol 17:2401-12
Yang, B S; Hauser, C A; Henkel, G et al. (1996) Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2. Mol Cell Biol 16:538-47
Galang, C K; Garcia-Ramirez, J; Solski, P A et al. (1996) Oncogenic Neu/ErbB-2 increases ets, AP-1, and NF-kappaB-dependent gene expression, and inhibiting ets activation blocks Neu-mediated cellular transformation. J Biol Chem 271:7992-8