Continued expansion and enhancement of the Mammography Tumor Registry (MTR) in Washington State is proposed in order to build a foundation for collaborative interdisciplinary research on mammography performance in a community setting. New methods for measuring the performance of mammography will be developed which will rely only on the dates of diagnosis and mammograms and characteristics of the tumor, in order to obviate the use of mammographers' coding of the reason for the mammogram, symptoms, assessment, or recommendations for follow up. The methods will be evaluated by analyzing variation in performance among facilities using new and standard methods as well as by using a simulation model to generate a gold standard. Using these measures, the roles of tumor biology, breast density, and hormone use in the failure of mammography will be investigated. The MTR will be expanded by adding 20 facilities selected for their potential contribution to research goals, and enhanced by adding a pathologist, surgeon, medical oncologist/cancer geneticist, and statistician to the investigator team. The database will be enhanced by including measurement of tumor biology (cell proliferation and genetic markers) in selected cases in which characteristics of the patient and mammograms are known. A pilot study is proposed to assess the feasibility of adding electronically transmitted pathology data directly to the MTR to allow timely feedback to mammography facilities to assist them in MQSA compliance. An ancillary study is proposed involving retrospective review of prior films ofrandontly selected cases diagnosed in TNM stage III or IV despite screening in the preceding 2-26 month period.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Project (R01)
Project #
Application #
Study Section
Health Systems Research (HSR)
Program Officer
Ballard-Barbash, Rachel
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Fred Hutchinson Cancer Research Center
United States
Zip Code
Urban, Nicole; Longton, Gary M; Crowe, Andrea D et al. (2007) Computer-assisted mammography feedback program (CAMFP) an electronic tool for continuing medical education. Acad Radiol 14:1036-42
Geller, Berta M; Kerlikowske, Karla; Carney, Patricia A et al. (2003) Mammography surveillance following breast cancer. Breast Cancer Res Treat 81:107-15
Geller, Berta M; Barlow, William E; Ballard-Barbash, Rachel et al. (2002) Use of the American College of Radiology BI-RADS to report on the mammographic evaluation of women with signs and symptoms of breast disease. Radiology 222:536-42
Taplin, Stephen H; Ichikawa, Laura E; Kerlikowske, Karla et al. (2002) Concordance of breast imaging reporting and data system assessments and management recommendations in screening mammography. Radiology 222:529-35
Kerlikowske, K; Carney, P A; Geller, B et al. (2000) Performance of screening mammography among women with and without a first-degree relative with breast cancer. Ann Intern Med 133:855-63
McIntosh, M W (1999) Instrumental variables when evaluating screening trials: estimating the benefit of detecting cancer by screening. Stat Med 18:2775-94
McIntosh, M W; Rubin, D B (1999) On estimating the causal effects of DNR orders. Med Care 37:722-6
Edlefsen, K L; Mandelson, M T; McIntosh, M W et al. (1999) Prostate-specific antigen for prostate cancer screening. Do physician characteristics affect its use? Am J Prev Med 17:87-90
Andersen, M R; Urban, N (1999) Involvement in decision-making and breast cancer survivor quality of life. Ann Behav Med 21:201-9
Lehman, C D; White, E; Peacock, S et al. (1999) Effect of age and breast density on screening mammograms with false-positive findings. AJR Am J Roentgenol 173:1651-5

Showing the most recent 10 out of 13 publications