Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA063173-02
Application #
2104864
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1995-01-01
Project End
1997-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Fox Chase Cancer Center
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19111
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Belinsky, M G; Kruh, G D (1999) MOAT-E (ARA) is a full-length MRP/cMOAT subfamily transporter expressed in kidney and liver. Br J Cancer 80:1342-9
Lee, K; Belinsky, M G; Bell, D W et al. (1998) Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter. Cancer Res 58:2741-7
Belinsky, M G; Bain, L J; Balsara, B B et al. (1998) Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. J Natl Cancer Inst 90:1735-41
Paul, S; Belinsky, M G; Shen, H et al. (1996) Structure and in vitro substrate specificity of the murine multidrug resistance-associated protein. Biochemistry 35:13647-55
Shen, H; Paul, S; Breuninger, L M et al. (1996) Cellular and in vitro transport of glutathione conjugates by MRP. Biochemistry 35:5719-25
Paul, S; Breuninger, L M; Kruh, G D (1996) ATP-dependent transport of lipophilic cytotoxic drugs by membrane vesicles prepared from MRP-overexpressing HL60/ADR cells. Biochemistry 35:14003-11
Paul, S; Breuninger, L M; Tew, K D et al. (1996) ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter. Proc Natl Acad Sci U S A 93:6929-34
Breuninger, L M; Paul, S; Gaughan, K et al. (1995) Expression of multidrug resistance-associated protein in NIH/3T3 cells confers multidrug resistance associated with increased drug efflux and altered intracellular drug distribution. Cancer Res 55:5342-7
Kruh, G D; Gaughan, K T; Godwin, A et al. (1995) Expression pattern of MRP in human tissues and adult solid tumor cell lines. J Natl Cancer Inst 87:1256-8