Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA063264-02
Application #
2105010
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1995-07-13
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Pathology
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
McDaid, J R; Loughery, J; Dunne, P et al. (2009) MLH1 mediates PARP-dependent cell death in response to the methylating agent N-methyl-N-nitrosourea. Br J Cancer 101:441-51
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Lehner, Kevin R; Stone, Megan M; Farber, Rosann A et al. (2007) Ninety-six haploid yeast strains with individual disruptions of open reading frames between YOR097C and YOR192C, constructed for the Saccharomyces genome deletion project, have an additional mutation in the mismatch repair gene MSH3. Genetics 177:1951-3
Hatch, Stephanie B; Lightfoot Jr, Harry M; Garwacki, Christopher P et al. (2005) Microsatellite instability testing in colorectal carcinoma: choice of markers affects sensitivity of detection of mismatch repair-deficient tumors. Clin Cancer Res 11:2180-7
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Hatch, Stephanie B; Farber, Rosann A (2004) Mutation rates in the complex microsatellite MYCL1 and related simple repeats in cultured human cells. Mutat Res 545:117-26
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Yamada, N A; Castro, A; Farber, R A (2003) Variation in the extent of microsatellite instability in human cell lines with defects in different mismatch repair genes. Mutagenesis 18:277-82
Boyer, Jayne C; Yamada, Nazumi A; Roques, C Natalia et al. (2002) Sequence dependent instability of mononucleotide microsatellites in cultured mismatch repair proficient and deficient mammalian cells. Hum Mol Genet 11:707-13
Yamada, Nazumi A; Smith, Gwynedd A; Castro, Anay et al. (2002) Relative rates of insertion and deletion mutations in dinucleotide repeats of various lengths in mismatch repair proficient mouse and mismatch repair deficient human cells. Mutat Res 499:213-25

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