Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA063350-01A2
Application #
2105142
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1996-04-09
Project End
2001-01-31
Budget Start
1996-04-09
Budget End
1997-01-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Surgery
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Sasaki, Kotaro; Pardee, Angela D; Qu, Yanyan et al. (2009) IL-4 suppresses very late antigen-4 expression which is required for therapeutic Th1 T-cell trafficking into tumors. J Immunother 32:793-802
Sasaki, Kotaro; Zhao, Xi; Pardee, Angela D et al. (2008) Stat6 signaling suppresses VLA-4 expression by CD8+ T cells and limits their ability to infiltrate tumor lesions in vivo. J Immunol 181:104-8
Sasaki, Kotaro; Pardee, Angela D; Okada, Hideho et al. (2008) IL-4 inhibits VLA-4 expression on Tc1 cells resulting in poor tumor infiltration and reduced therapy benefit. Eur J Immunol 38:2865-73
Berhanu, Aklile; Huang, Jian; Watkins, Simon C et al. (2007) Treatment-enhanced CD4+Foxp3+ glucocorticoid-induced TNF receptor family related high regulatory tumor-infiltrating T cells limit the effectiveness of cytokine-based immunotherapy. J Immunol 178:3400-8
Berhanu, Aklile; Huang, Jian; Alber, Sean M et al. (2006) Combinational FLt3 ligand and granulocyte macrophage colony-stimulating factor treatment promotes enhanced tumor infiltration by dendritic cells and antitumor CD8(+) T-cell cross-priming but is ineffective as a therapy. Cancer Res 66:4895-903
Bjorck, P; Coates, P T H; Wang, Z et al. (2005) Promotion of long-term heart allograft survival by combination of mobilized donor plasmacytoid dendritic cells and anti-CD154 monoclonal antibody. J Heart Lung Transplant 24:1118-20
Huang, Jian; Tatsumi, Tomohide; Pizzoferrato, Eva et al. (2005) Nitric oxide sensitizes tumor cells to dendritic cell-mediated apoptosis, uptake, and cross-presentation. Cancer Res 65:8461-70
Bjorck, Pia (2004) Dendritic cells exposed to herpes simplex virus in vivo do not produce IFN-alpha after rechallenge with virus in vitro and exhibit decreased T cell alloreactivity. J Immunol 172:5396-404
Tatsumi, Tomohide; Huang, Jian; Gooding, William E et al. (2003) Intratumoral delivery of dendritic cells engineered to secrete both interleukin (IL)-12 and IL-18 effectively treats local and distant disease in association with broadly reactive Tc1-type immunity. Cancer Res 63:6378-86
Tatsumi, Tomohide; Gambotto, Andrea; Robbins, Paul D et al. (2002) Interleukin 18 gene transfer expands the repertoire of antitumor Th1-type immunity elicited by dendritic cell-based vaccines in association with enhanced therapeutic efficacy. Cancer Res 62:5853-8

Showing the most recent 10 out of 11 publications