Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA063363-03
Application #
2105161
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1994-05-01
Project End
1998-02-28
Budget Start
1996-03-20
Budget End
1997-02-28
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Ohio State University
Department
Type
Schools of Pharmacy
DUNS #
098987217
City
Columbus
State
OH
Country
United States
Zip Code
43210
Au, Jessie L-S; Jang, Seong H; Wientjes, M Guill (2002) Clinical aspects of drug delivery to tumors. J Control Release 78:81-95
Au, J L; Jang, S H; Zheng, J et al. (2001) Determinants of drug delivery and transport to solid tumors. J Control Release 74:31-46
Li, D; Au, J L (2001) Mdr1 transfection causes enhanced apoptosis by paclitaxel: an effect independent of drug efflux function of P-glycoprotein. Pharm Res 18:907-13
Jang, S H; Wientjes, M G; Au, J L (2001) Enhancement of paclitaxel delivery to solid tumors by apoptosis-inducing pretreatment: effect of treatment schedule. J Pharmacol Exp Ther 296:1035-42
Jang, S H; Wientjes, M G; Au, J L (2001) Kinetics of P-glycoprotein-mediated efflux of paclitaxel. J Pharmacol Exp Ther 298:1236-42
Jang, S H; Wientjes, M G; Au, J L (2001) Determinants of paclitaxel uptake, accumulation and retention in solid tumors. Invest New Drugs 19:113-23
Millenbaugh, N J; Wientjes, M G; Au, J L (2000) A pharmacodynamic analysis method to determine the relative importance of drug concentration and treatment time on effect. Cancer Chemother Pharmacol 45:265-72
Kuh, H J; Jang, S H; Wientjes, M G et al. (2000) Computational model of intracellular pharmacokinetics of paclitaxel. J Pharmacol Exp Ther 293:761-70
Song, S; Wientjes, M G; Gan, Y et al. (2000) Fibroblast growth factors: an epigenetic mechanism of broad spectrum resistance to anticancer drugs. Proc Natl Acad Sci U S A 97:8658-63
Kuh, H J; Jang, S H; Wientjes, M G et al. (1999) Determinants of paclitaxel penetration and accumulation in human solid tumor. J Pharmacol Exp Ther 290:871-80

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