Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA063624-02
Application #
2105596
Study Section
Experimental Immunology Study Section (EI)
Project Start
1995-01-01
Project End
1997-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Center for Molecular Medicine/Immunology
Department
Type
DUNS #
City
Belleville
State
NJ
Country
United States
Zip Code
07950
Ong, G L; Mattes, M J (2000) Limitations in the use of low pH extraction to distinguish internalized from cell surface-bound radiolabeled antibody. Nucl Med Biol 27:571-5
Griffiths, G L; Govindan, S V; Sgouros, G et al. (1999) Cytotoxicity with Auger electron-emitting radionuclides delivered by antibodies. Int J Cancer 81:985-92
Patel, S; Stein, R; Ong, G L et al. (1999) Enhancement of tumor-to-nontumor localization ratios by hepatocyte-directed blood clearance of antibodies labeled with certain residualizing radiolabels. J Nucl Med 40:1392-401
Ong, G L; Mattes, M J (1999) Processing of antibodies to the MHC class II antigen by B-cell lymphomas: release of Fab-like fragments into the medium. Mol Immunol 36:777-88
Ong, G L; Mattes, M J (1998) The processing of antibodies bound to B-cell lymphomas: the effect of inadvertent mycoplasma contamination. In Vitro Cell Dev Biol Anim 34:527-8
Reddy, N; Ong, G L; Behr, T M et al. (1998) Rapid blood clearance of mouse IgG2a and human IgG1 in many nude and nu/+ mouse strains is due to low IgG2a serum concentrations. Cancer Immunol Immunother 46:25-33
Karacay, H; Ong, G L; Hansen, H J et al. (1998) Intracellular processing of 99Tcm-antibody conjugates. Nucl Med Commun 19:971-9
Vangeepuram, N; Ong, G L; Mattes, M J (1997) Processing of antibodies bound to B-cell lymphomas and lymphoblastoid cell lines. Cancer 80:2425-30
Mattes, M J; Shih, L B; Govindan, S V et al. (1997) The advantage of residualizing radiolabels for targeting B-cell lymphomas with a radiolabeled anti-CD22 monoclonal antibody. Int J Cancer 71:429-35
Stein, R; Goldenberg, D M; Ong, G L et al. (1997) Manipulation of blood clearance to optimize delivery of residualizing label-antibody conjugates to tumor cells in vivo. J Nucl Med 38:1392-400

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