Abstract

This is a collaborative group investigation to study the potential risks or preventive properties of exogenous hormones and prophylactic surgery for breast and ovarian cancer development in BRCA1 and BRCA2 carriers. The goals of this study are to: 1) identify families with BRCA1 and BRCA2 mutations; 2) establish whether oral contraceptive use protects against ovarian cancers in carriers of BRCA1 mutations; 3) establish whether tubal ligation protects against ovarian cancer in carriers of BRCA1 and BRCA2 mutations; 4) establish whether oral contraceptive use increases the risk of breast cancer in BRCA1 and BRCA2 mutation carriers; 5) establish whether hormone replacement therapy increases the risk of breast cancer in carriers of BRCA1 and BRCA2 mutations; 6) establish if oophorectomy is associated with a reduction in mortality from ovarian cancer in comparison to observational therapy; 7) establish if an oophorectomy reduces the risk of breast cancer; and 8) establish if a prophylactic mastectomy reduces the mortality from breast cancer in comparison to mammographic screening.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA063678-05
Application #
2769765
Study Section
Special Emphasis Panel (ZRG4-EDC-2 (02))
Program Officer
Seminara, Daniela
Project Start
1994-09-15
Project End
2000-08-31
Budget Start
1998-09-01
Budget End
1999-08-31
Support Year
5
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of Toronto
Department
Type
DUNS #
259999779
City
Toronto
State
ON
Country
Canada
Zip Code
M5 1-S8

  Publications

Harris, Holly R; Babic, Ana; Webb, Penelope M et al. (2018) Polycystic Ovary Syndrome, Oligomenorrhea, and Risk of Ovarian Cancer Histotypes: Evidence from the Ovarian Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev 27:174-182
Lu, Yingchang; Beeghly-Fadiel, Alicia; Wu, Lang et al. (2018) A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk. Cancer Res 78:5419-5430
Liu, Gang; Mukherjee, Bhramar; Lee, Seunggeun et al. (2018) Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence. Am J Epidemiol 187:366-377
Ong, Jue-Sheng; Hwang, Liang-Dar; Cuellar-Partida, Gabriel et al. (2018) Assessment of moderate coffee consumption and risk of epithelial ovarian cancer: a Mendelian randomization study. Int J Epidemiol 47:450-459
Reid, Brett M; Permuth, Jennifer B; Chen, Y Ann et al. (2017) Integration of Population-Level Genotype Data with Functional Annotation Reveals Over-Representation of Long Noncoding RNAs at Ovarian Cancer Susceptibility Loci. Cancer Epidemiol Biomarkers Prev 26:116-125
Kotsopoulos, Joanne; Sopik, Victoria; Rosen, Barry et al. (2017) Frequency of germline PALB2 mutations among women with epithelial ovarian cancer. Fam Cancer 16:29-34
Kar, Siddhartha P; Adler, Emily; Tyrer, Jonathan et al. (2017) Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci. Br J Cancer 116:524-535
Rasmussen, Christina B; Kjaer, Susanne K; Albieri, Vanna et al. (2017) Pelvic Inflammatory Disease and the Risk of Ovarian Cancer and Borderline Ovarian Tumors: A Pooled Analysis of 13 Case-Control Studies. Am J Epidemiol 185:8-20
Akbari, Mohammad R; Zhang, Shiyu; Cragun, Deborah et al. (2017) Correlation between germline mutations in MMR genes and microsatellite instability in ovarian cancer specimens. Fam Cancer 16:351-355
Kim, Shana J; Rosen, Barry; Fan, Isabel et al. (2017) Epidemiologic factors that predict long-term survival following a diagnosis of epithelial ovarian cancer. Br J Cancer 116:964-971

Showing the most recent 10 out of 61 publications