Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA063753-03
Application #
2105809
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1994-06-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Virginia Commonwealth University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298
Bose, Prithviraj; Grant, Steven (2015) Rational Combinations of Targeted Agents in AML. J Clin Med 4:634-64
Dasmahapatra, Girija; Patel, Hiral; Friedberg, Johnathan et al. (2014) In vitro and in vivo interactions between the HDAC6 inhibitor ricolinostat (ACY1215) and the irreversible proteasome inhibitor carfilzomib in non-Hodgkin lymphoma cells. Mol Cancer Ther 13:2886-97
Dasmahapatra, Girija; Patel, Hiral; Nguyen, Tri et al. (2013) PLK1 inhibitors synergistically potentiate HDAC inhibitor lethality in imatinib mesylate-sensitive or -resistant BCR/ABL+ leukemia cells in vitro and in vivo. Clin Cancer Res 19:404-14
Hamed, Hossein A; Das, Swadesh K; Sokhi, Upneet K et al. (2013) Combining histone deacetylase inhibitors with MDA-7/IL-24 enhances killing of renal carcinoma cells. Cancer Biol Ther 14:1039-49
Hamed, Hossein A; Yacoub, Adly; Park, Margaret A et al. (2013) Histone deacetylase inhibitors interact with melanoma differentiation associated-7/interleukin-24 to kill primary human glioblastoma cells. Mol Pharmacol 84:171-81
Dasmahapatra, Girija; Patel, Hiral; Dent, Paul et al. (2013) The Bruton tyrosine kinase (BTK) inhibitor PCI-32765 synergistically increases proteasome inhibitor activity in diffuse large-B cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) cells sensitive or resistant to bortezomib. Br J Haematol 161:43-56
Booth, Laurence; Cazanave, Sophie C; Hamed, Hossein A et al. (2012) OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killing. Cancer Biol Ther 13:224-36
Booth, Laurence; Cruickshanks, Nichola; Ridder, Thomas et al. (2012) OSU-03012 interacts with lapatinib to kill brain cancer cells. Cancer Biol Ther 13:1501-11
Rahmani, Mohamed; Aust, Mandy Mayo; Attkisson, Elisa et al. (2012) Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process. Blood 119:6089-98
Dasmahapatra, Girija; Lembersky, Dmitry; Son, Minkyeong P et al. (2012) Obatoclax interacts synergistically with the irreversible proteasome inhibitor carfilzomib in GC- and ABC-DLBCL cells in vitro and in vivo. Mol Cancer Ther 11:1122-32

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