Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA064524-02S1
Application #
2107060
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1995-05-01
Project End
2000-02-29
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Pharmacology
Type
Other Domestic Higher Education
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Salzberg, A A; Dedon, P C (2000) DNA bending is a determinant of calicheamicin target recognition. Biochemistry 39:7605-12
Burney, S; Niles, J C; Dedon, P C et al. (1999) DNA damage in deoxynucleosides and oligonucleotides treated with peroxynitrite. Chem Res Toxicol 12:513-20
Chaudhry, M A; Dedon, P C; Wilson 3rd, D M et al. (1999) Removal by human apurinic/apyrimidinic endonuclease 1 (Ape 1) and Escherichia coli exonuclease III of 3'-phosphoglycolates from DNA treated with neocarzinostatin, calicheamicin, and gamma-radiation. Biochem Pharmacol 57:531-8
Dedon, P C; Plastaras, J P; Rouzer, C A et al. (1998) Indirect mutagenesis by oxidative DNA damage: formation of the pyrimidopurinone adduct of deoxyguanosine by base propenal. Proc Natl Acad Sci U S A 95:11113-6
Kennedy, L J; Moore Jr, K; Caulfield, J L et al. (1997) Quantitation of 8-oxoguanine and strand breaks produced by four oxidizing agents. Chem Res Toxicol 10:386-92
LaMarr, W A; Sandman, K M; Reeve, J N et al. (1997) Differential effects of DNA supercoiling on radical-mediated DNA strand breaks. Chem Res Toxicol 10:1118-22
Liang, Q; Choi, D J; Dedon, P C (1997) Calicheamin-mediated DNA damage in a reconstituted nucleosome is not affected by histone acetylation: the role of drug structure in the target recognition process. Biochemistry 36:12653-9
LaMarr, W A; Sandman, K M; Reeve, J N et al. (1997) Large scale preparation of positively supercoiled DNA using the archaeal histone HMf. Nucleic Acids Res 25:1660-1
Mathur, P; Xu, J; Dedon, P C (1997) Cytosine methylation enhances DNA damage produced by groove binding and intercalating enediynes: studies with esperamicins A1 and C. Biochemistry 36:14868-73
Salzberg, A A; Dedon, P C (1997) An improved method for the rapid assessment of DNA bending by small molecules. J Biomol Struct Dyn 15:277-84

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