Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA064556-03
Application #
2107112
Study Section
Pathology B Study Section (PTHB)
Project Start
1994-08-01
Project End
1999-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Pathology
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Dowds, Theresa A; Masumoto, Junya; Zhu, Li et al. (2004) Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC. J Biol Chem 279:21924-8
Dowds, Theresa A; Masumoto, Junya; Chen, Felicia F et al. (2003) Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product. Biochem Biophys Res Commun 302:575-80
Masumoto, Junya; Dowds, Theresa A; Schaner, Philip et al. (2003) ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis. Biochem Biophys Res Commun 303:69-73
Masumoto, Junya; Zhou, Weibin; Chen, Felicia F et al. (2003) Caspy, a zebrafish caspase, activated by ASC oligomerization is required for pharyngeal arch development. J Biol Chem 278:4268-76
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del Peso, L; Gonzalez, V M; Inohara, N et al. (2000) Disruption of the CED-9.CED-4 complex by EGL-1 is a critical step for programmed cell death in Caenorhabditis elegans. J Biol Chem 275:27205-11

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