Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA064556-03
Application #
2107112
Study Section
Pathology B Study Section (PTHB)
Project Start
1994-08-01
Project End
1999-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Pathology
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Dowds, Theresa A; Masumoto, Junya; Zhu, Li et al. (2004) Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC. J Biol Chem 279:21924-8
Dowds, Theresa A; Masumoto, Junya; Chen, Felicia F et al. (2003) Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product. Biochem Biophys Res Commun 302:575-80
Masumoto, Junya; Dowds, Theresa A; Schaner, Philip et al. (2003) ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis. Biochem Biophys Res Commun 303:69-73
Masumoto, Junya; Zhou, Weibin; Chen, Felicia F et al. (2003) Caspy, a zebrafish caspase, activated by ASC oligomerization is required for pharyngeal arch development. J Biol Chem 278:4268-76
Inohara, Naohiro; Ogura, Yasunori; Nunez, Gabriel (2002) Nods: a family of cytosolic proteins that regulate the host response to pathogens. Curr Opin Microbiol 5:76-80
Liu, J Rebecca; Opipari, Anthony W; Tan, Lijun et al. (2002) Dysfunctional apoptosome activation in ovarian cancer: implications for chemoresistance. Cancer Res 62:924-31
Ogura, Y; Inohara, N; Benito, A et al. (2001) Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J Biol Chem 276:4812-8
Inohara, N; Ogura, Y; Chen, F F et al. (2001) Human Nod1 confers responsiveness to bacterial lipopolysaccharides. J Biol Chem 276:2551-4
Inohara, N; Nunez, G (2001) The NOD: a signaling module that regulates apoptosis and host defense against pathogens. Oncogene 20:6473-81
Inohara, N; Koseki, T; Lin, J et al. (2000) An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways. J Biol Chem 275:27823-31

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