Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA064803-03
Application #
2107493
Study Section
Special Emphasis Panel (SRC (88))
Project Start
1994-09-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Pathology
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Orth, K; Dixit, V M (1997) Bik and Bak induce apoptosis downstream of CrmA but upstream of inhibitor of apoptosis. J Biol Chem 272:8841-4
Duan, H; Chinnaiyan, A M; Hudson, P L et al. (1996) ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis. J Biol Chem 271:1621-5
Duan, H; Orth, K; Chinnaiyan, A M et al. (1996) ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J Biol Chem 271:16720-4
Chinnaiyan, A M; Tepper, C G; Seldin, M F et al. (1996) FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis. J Biol Chem 271:4961-5
Orth, K; Chinnaiyan, A M; Garg, M et al. (1996) The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A. J Biol Chem 271:16443-6
Chinnaiyan, A M; Orth, K; O'Rourke, K et al. (1996) Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases. J Biol Chem 271:4573-6
Orth, K; O'Rourke, K; Salvesen, G S et al. (1996) Molecular ordering of apoptotic mammalian CED-3/ICE-like proteases. J Biol Chem 271:20977-80
Beidler, D R; Tewari, M; Friesen, P D et al. (1995) The baculovirus p35 protein inhibits Fas- and tumor necrosis factor-induced apoptosis. J Biol Chem 270:16526-8
Tewari, M; Beidler, D R; Dixit, V M (1995) CrmA-inhibitable cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein during Fas- and tumor necrosis factor-induced apoptosis. J Biol Chem 270:18738-41
Rothe, M; Sarma, V; Dixit, V M et al. (1995) TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40. Science 269:1424-7

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