Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA065559-01A2
Application #
2108584
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1996-07-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Fox Chase Cancer Center
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19111
Adams, Gregory P; Shaller, Calvin C; Dadachova, Ekaterina et al. (2004) A single treatment of yttrium-90-labeled CHX-A""-C6.5 diabody inhibits the growth of established human tumor xenografts in immunodeficient mice. Cancer Res 64:6200-6
Adams, G P; Schier, R; McCall, A M et al. (2001) High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules. Cancer Res 61:4750-5
Powers, D B; Amersdorfer, P; Poul, M et al. (2001) Expression of single-chain Fv-Fc fusions in Pichia pastoris. J Immunol Methods 251:123-35
McCall, A M; Shahied, L; Amoroso, A R et al. (2001) Increasing the affinity for tumor antigen enhances bispecific antibody cytotoxicity. J Immunol 166:6112-7
Nielsen, U B; Adams, G P; Weiner, L M et al. (2000) Targeting of bivalent anti-ErbB2 diabody antibody fragments to tumor cells is independent of the intrinsic antibody affinity. Cancer Res 60:6434-40
Adams, G P; Shaller, C C; Chappell, L L et al. (2000) Delivery of the alpha-emitting radioisotope bismuth-213 to solid tumors via single-chain Fv and diabody molecules. Nucl Med Biol 27:339-46
Weiner, L M; Adams, G P (2000) New approaches to antibody therapy. Oncogene 19:6144-51
McCall, A M; Adams, G P; Amoroso, A R et al. (1999) Isolation and characterization of an anti-CD16 single-chain Fv fragment and construction of an anti-HER2/neu/anti-CD16 bispecific scFv that triggers CD16-dependent tumor cytolysis. Mol Immunol 36:433-45
Adams, G P; Schier, R (1999) Generating improved single-chain Fv molecules for tumor targeting. J Immunol Methods 231:249-60
McCall, A M; Amoroso, A R; Sautes, C et al. (1998) Characterization of anti-mouse Fc gamma RII single-chain Fv fragments derived from human phage display libraries. Immunotechnology 4:71-87

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