Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA065579-01A2
Application #
2108617
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1996-07-03
Project End
1999-06-30
Budget Start
1996-07-03
Budget End
1997-06-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Kentucky
Department
Other Clinical Sciences
Type
Schools of Allied Health Profes
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506
Romagnolo, Donato F; Chirnomas, Ryan B; Ku, Jennifer et al. (2003) Deoxycholate, an endogenous tumor promoter and DNA damaging agent, modulates BRCA-1 expression in apoptosis-sensitive epithelial cells: loss of BRCA-1 expression in colonic adenocarcinomas. Nutr Cancer 46:82-92
Bernstein, Carol; Bernstein, Harris; Payne, Claire M et al. (2002) DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis. Mutat Res 511:145-78
Bernstein, Harris; Holubec, Hana; Warneke, James A et al. (2002) Patchy field defects of apoptosis resistance and dedifferentiation in flat mucosa of colon resections from colon cancer patients. Ann Surg Oncol 9:505-17
Jacobson, E L; Giacomoni, P U; Roberts, M J et al. (2001) Optimizing the energy status of skin cells during solar radiation. J Photochem Photobiol B 63:141-7
Katschinski, D M; Jacobson, E L; Wiedemann, G J et al. (2001) Modulation of VP-16 cytotoxicity by carboplatin and 41.8 degrees C hyperthermia. J Cancer Res Clin Oncol 127:425-32
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Jacobson, M K; Jacobson, E L (1999) Discovering new ADP-ribose polymer cycles: protecting the genome and more. Trends Biochem Sci 24:415-7
Shieh, W M; Ame, J C; Wilson, M V et al. (1998) Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers. J Biol Chem 273:30069-72
Jacobson, E L; Jacobson, M K (1997) Tissue NAD as a biochemical measure of niacin status in humans. Methods Enzymol 280:221-30