Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA065656-02
Application #
2108720
Study Section
Molecular and Cellular Biophysics Study Section (BBCA)
Project Start
1995-03-01
Project End
1999-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Washington
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Wisedchaisri, Goragot; Wu, Meiting; Sherman, David R et al. (2008) Crystal structures of the response regulator DosR from Mycobacterium tuberculosis suggest a helix rearrangement mechanism for phosphorylation activation. J Mol Biol 378:227-42
Wisedchaisri, Goragot; Chou, C James; Wu, Meiting et al. (2007) Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis. Biochemistry 46:436-47
Davies, Douglas R; Mushtaq, Adeel; Interthal, Heidrun et al. (2006) The structure of the transition state of the heterodimeric topoisomerase I of Leishmania donovani as a vanadate complex with nicked DNA. J Mol Biol 357:1202-10
Wisedchaisri, Goragot; Wu, Meiting; Rice, Adrian E et al. (2005) Structures of Mycobacterium tuberculosis DosR and DosR-DNA complex involved in gene activation during adaptation to hypoxic latency. J Mol Biol 354:630-41
Chou, C James; Wisedchaisri, Goragot; Monfeli, Ryan R et al. (2004) Functional studies of the Mycobacterium tuberculosis iron-dependent regulator. J Biol Chem 279:53554-61
Wisedchaisri, Goragot; Holmes, Randall K; Hol, Wim G J (2004) Crystal structure of an IdeR-DNA complex reveals a conformational change in activated IdeR for base-specific interactions. J Mol Biol 342:1155-69
Quigley, Paulene M; Korotkov, Konstantin; Baneyx, Francois et al. (2004) A new native EcHsp31 structure suggests a key role of structural flexibility for chaperone function. Protein Sci 13:269-77
Davies, Douglas R; Interthal, Heidrun; Champoux, James J et al. (2004) Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes. J Med Chem 47:829-37
Sastry, M S R; Quigley, Paulene M; Hol, Wim G J et al. (2004) The linker-loop region of Escherichia coli chaperone Hsp31 functions as a gate that modulates high-affinity substrate binding at elevated temperatures. Proc Natl Acad Sci U S A 101:8587-92
Davies, Douglas R; Interthal, Heidrun; Champoux, James J et al. (2003) Crystal structure of a transition state mimic for Tdp1 assembled from vanadate, DNA, and a topoisomerase I-derived peptide. Chem Biol 10:139-47

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