Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA066134-02
Application #
2109384
Study Section
Pathology B Study Section (PTHB)
Project Start
1995-09-01
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Pathology
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Cross, Janet V; Templeton, Dennis J (2004) Oxidative stress inhibits MEKK1 by site-specific glutathionylation in the ATP-binding domain. Biochem J 381:675-83
Zhang, Donna D; Lo, Shih-Ching; Cross, Janet V et al. (2004) Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol 24:10941-53
Seanor, Krista L; Cross, Janet V; Nguyen, Suzanne M et al. (2003) Reactive quinones differentially regulate SAPK/JNK and p38/mHOG stress kinases. Antioxid Redox Signal 5:103-13
Cross, J V; Deak, J C; Rich, E A et al. (1999) Quinone reductase inhibitors block SAPK/JNK and NFkappaB pathways and potentiate apoptosis. J Biol Chem 274:31150-4
Deak, J C; Cross, J V; Lewis, M et al. (1998) Fas-induced proteolytic activation and intracellular redistribution of the stress-signaling kinase MEKK1. Proc Natl Acad Sci U S A 95:5595-600
Deak, J C; Templeton, D J (1997) Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domain. Biochem J 322 ( Pt 1):185-92