Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA066141-08
Application #
2109395
Study Section
Virology Study Section (VR)
Project Start
1989-08-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Genetics
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Jiang, Canping; Wechuck, James B; Goins, William F et al. (2004) Immobilized cobalt affinity chromatography provides a novel, efficient method for herpes simplex virus type 1 gene vector purification. J Virol 78:8994-9006
Fink, D J; DeLuca, N A; Yamada, M et al. (2000) Design and application of HSV vectors for neuroprotection. Gene Ther 7:115-9
Akkaraju, G R; Huard, J; Hoffman, E P et al. (1999) Herpes simplex virus vector-mediated dystrophin gene transfer and expression in MDX mouse skeletal muscle. J Gene Med 1:280-9
Krisky, D M; Marconi, P C; Oligino, T J et al. (1998) Development of herpes simplex virus replication-defective multigene vectors for combination gene therapy applications. Gene Ther 5:1517-30
Laquerre, S; Anderson, D B; Stolz, D B et al. (1998) Recombinant herpes simplex virus type 1 engineered for targeted binding to erythropoietin receptor-bearing cells. J Virol 72:9683-97
Krisky, D M; Wolfe, D; Goins, W F et al. (1998) Deletion of multiple immediate-early genes from herpes simplex virus reduces cytotoxicity and permits long-term gene expression in neurons. Gene Ther 5:1593-603
Laquerre, S; Argnani, R; Anderson, D B et al. (1998) Heparan sulfate proteoglycan binding by herpes simplex virus type 1 glycoproteins B and C, which differ in their contributions to virus attachment, penetration, and cell-to-cell spread. J Virol 72:6119-30
Laquerre, S; Anderson, D B; Argnani, R et al. (1998) Herpes simplex virus type 1 glycoprotein B requires a cysteine residue at position 633 for folding, processing, and incorporation into mature infectious virus particles. J Virol 72:4940-9
Laquerre, S; Person, S; Glorioso, J C (1996) Glycoprotein B of herpes simplex virus type 1 oligomerizes through the intermolecular interaction of a 28-amino-acid domain. J Virol 70:1640-50
Huard, J; Feero, W G; Watkins, S C et al. (1996) The basal lamina is a physical barrier to herpes simplex virus-mediated gene delivery to mature muscle fibers. J Virol 70:8117-23