Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA066741-01A1
Application #
2110198
Study Section
Pathology B Study Section (PTHB)
Project Start
1996-04-03
Project End
2001-01-31
Budget Start
1996-04-03
Budget End
1997-01-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Genetics
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Zilfou, J T; Hoffman, W H; Sank, M et al. (2001) The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation. Mol Cell Biol 21:3974-85
Brown, C Y; Mize, G J; Pineda, M et al. (1999) Role of two upstream open reading frames in the translational control of oncogene mdm2. Oncogene 18:5631-7
Murphy, M; Ahn, J; Walker, K K et al. (1999) Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. Genes Dev 13:2490-501
Sharp, D A; Kratowicz, S A; Sank, M J et al. (1999) Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein. J Biol Chem 274:38189-96
Meng, R D; Shih, H; Prabhu, N S et al. (1998) Bypass of abnormal MDM2 inhibition of p53-dependent growth suppression. Clin Cancer Res 4:251-9
Landers, J E; Cassel, S L; George, D L (1997) Translational enhancement of mdm2 oncogene expression in human tumor cells containing a stabilized wild-type p53 protein. Cancer Res 57:3562-8