We propose to develop and evaluate Magnetic Resonance Imaging (MRI) pulse sequences to detect breast cancer and distinguish it from benign breast disease; and to develop and evaluate MRI-guided biopsy techniques. We will develop and optimize a new, ultra-fast spiral k- space MR pulse sequence that has fat suppression, magnetization transfer, and high resolution, and evaluate it with a pharmokinetic model. We will also optimize an existing high resolution three- dimensional spectral-spatial volume acquisition magnetization transfer (3DSSMT) pulse sequence. MR-compatible biopsy techniques with 14- gauge large core needles will be developed, and MR scan techniques for interactively guiding needle placement optimized. We will study 120 women with the optimized 3DSSMT and dynamic spiral k-space MR sequences to identify and characterize enhancing breast lesions. All lesions will be core biopsied with MRI guidance, a wire placed, and pathology confirmed by surgical excision of the wire localized lesion. We will use receiver operating characteristic (ROC) curves to measure the ability of the new MR technique to detect focal and multicentric breast cancer.
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| Kurian, Allison W; Munoz, Diego F; Rust, Peter et al. (2012) Online tool to guide decisions for BRCA1/2 mutation carriers. J Clin Oncol 30:497-506 |
| Kurian, Allison W; Sigal, Bronislava M; Plevritis, Sylvia K (2010) Survival analysis of cancer risk reduction strategies for BRCA1/2 mutation carriers. J Clin Oncol 28:222-31 |
| van de Ven, Stephanie M W Y; Lin, Margaret C; Daniel, Bruce L et al. (2010) Freehand MRI-guided preoperative needle localization of breast lesions after MRI-guided vacuum-assisted core needle biopsy without marker placement. J Magn Reson Imaging 32:101-9 |
| Han, Misung; Beatty, Philip J; Daniel, Bruce L et al. (2009) Independent slab-phase modulation combined with parallel imaging in bilateral breast MRI. Magn Reson Med 62:1221-31 |
| Han, Misung; Daniel, Bruce L; Hargreaves, Brian A (2008) Accelerated bilateral dynamic contrast-enhanced 3D spiral breast MRI using TSENSE. J Magn Reson Imaging 28:1425-34 |
| Kurian, Allison W; Hartman, Anne-Renee; Mills, Meredith A et al. (2008) Magnetic resonance galactography: a feasibility study in women with prior atypical breast duct cytology. Breast J 14:211-4 |
| Hargreaves, Brian A; Cunningham, Charles H; Pauly, John M et al. (2007) Independent phase modulation for efficient dual-band 3D imaging. Magn Reson Med 57:798-802 |
| Vidarsson, Logi; Cunningham, Charles; Gold, Garry E et al. (2007) T2-selective magnetization preparation pulses. IEEE Trans Med Imaging 26:981-9 |
| Plevritis, Sylvia K; Kurian, Allison W; Sigal, Bronislava M et al. (2006) Cost-effectiveness of screening BRCA1/2 mutation carriers with breast magnetic resonance imaging. JAMA 295:2374-84 |
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