Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA066971-09
Application #
6628310
Study Section
Metabolic Pathology Study Section (MEP)
Program Officer
Cole, John S
Project Start
1995-04-14
Project End
2005-01-31
Budget Start
2003-02-01
Budget End
2004-01-31
Support Year
9
Fiscal Year
2003
Total Cost
$318,000
Indirect Cost
Name
Thomas Jefferson University
Department
Pathology
Type
Schools of Medicine
DUNS #
053284659
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Feitelson, Mark A; Arzumanyan, Alla; Kulathinal, Rob J et al. (2015) Sustained proliferation in cancer: Mechanisms and novel therapeutic targets. Semin Cancer Biol 35 Suppl:S25-S54
Schinazi, Raymond F; Bassit, Leda; Clayton, Marcia M et al. (2012) Evaluation of single and combination therapies with tenofovir disoproxil fumarate and emtricitabine in vitro and in a robust mouse model supporting high levels of hepatitis B virus replication. Antimicrob Agents Chemother 56:6186-91
Pan, Jingbo; Lian, Zhaorui; Wallett, Sarah et al. (2007) The hepatitis B x antigen effector, URG7, blocks tumour necrosis factor alpha-mediated apoptosis by activation of phosphoinositol 3-kinase and beta-catenin. J Gen Virol 88:3275-85
Feitelson, Mark A; Clayton, Marcia M; Sun, Bill et al. (2007) Development of a novel mouse model to evaluate drug candidates against hepatitis B virus. Antivir Chem Chemother 18:213-23
Lian, Zhaorui; Liu, Jie; Wu, Mengchao et al. (2007) Hepatitis B x antigen up-regulates vascular endothelial growth factor receptor 3 in hepatocarcinogenesis. Hepatology 45:1390-9
Lian, Zhaorui; Liu, Jie; Li, Li et al. (2006) Enhanced cell survival of Hep3B cells by the hepatitis B x antigen effector, URG11, is associated with upregulation of beta-catenin. Hepatology 43:415-24
Liu, J; Lian, Z; Han, S et al. (2006) Downregulation of E-cadherin by hepatitis B virus X antigen in hepatocellullar carcinoma. Oncogene 25:1008-17
Feitelson, Mark Alan; Reis, Helena M G P V; Liu, Jie et al. (2005) Hepatitis B virus X antigen (HBxAg) and cell cycle control in chronic infection and hepatocarcinogenesis. Front Biosci 10:1558-72
Feitelson, Mark A; Pan, Jingbo; Lian, Zhaorui (2004) Early molecular and genetic determinants of primary liver malignancy. Surg Clin North Am 84:339-54
Norton, P A; Reis, H M G P V; Prince, S et al. (2004) Activation of fibronectin gene expression by hepatitis B virus x antigen. J Viral Hepat 11:332-41

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