Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA067224-02
Application #
2110847
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1995-04-15
Project End
2000-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
009214214
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Itano, Naoki; Okamoto, Shu-ichi; Zhang, Dongxian et al. (2003) Cell spreading controls endoplasmic and nuclear calcium: a physical gene regulation pathway from the cell surface to the nucleus. Proc Natl Acad Sci U S A 100:5181-6
Borges, E; Jan, Y; Ruoslahti, E (2000) Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain. J Biol Chem 275:39867-73
Wang, B; Zou, J X; Ek-Rylander, B et al. (2000) R-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras. J Biol Chem 275:5222-7
Ruoslahti, E (1999) Fibronectin and its integrin receptors in cancer. Adv Cancer Res 76:1-20
MacKenna, D A; Dolfi, F; Vuori, K et al. (1998) Extracellular signal-regulated kinase and c-Jun NH2-terminal kinase activation by mechanical stretch is integrin-dependent and matrix-specific in rat cardiac fibroblasts. J Clin Invest 101:301-10
Bourdoulous, S; Orend, G; MacKenna, D A et al. (1998) Fibronectin matrix regulates activation of RHO and CDC42 GTPases and cell cycle progression. J Cell Biol 143:267-76
Ruoslahti, E (1997) Integrins as signaling molecules and targets for tumor therapy. Kidney Int 51:1413-7
Schneller, M; Vuori, K; Ruoslahti, E (1997) Alphavbeta3 integrin associates with activated insulin and PDGFbeta receptors and potentiates the biological activity of PDGF. EMBO J 16:5600-7
Vuori, K; Hirai, H; Aizawa, S et al. (1996) Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases. Mol Cell Biol 16:2606-13
Zhang, Z; Vuori, K; Wang, H et al. (1996) Integrin activation by R-ras. Cell 85:61-9

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