Abstract

The investigator proposes a model and means for studying hypoxia/ischemia protective interventions. Oxygen levels, phosphate metabolites and cerebral blood flow will be studied in experiments that are as parallel as the measurements allow. The problems in making the different measurements at the same time were handled well in the introduction to the revised application. This is a revised application proposing the use of NMR and EPR to probe metabolic parameters related to ischemic and hypoxic brain.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA067431-01A2
Application #
2008860
Study Section
Biophysical Chemistry Study Section (BBCB)
Program Officer
Jacobs, Tom P
Project Start
1997-07-01
Project End
2000-06-30
Budget Start
1997-07-01
Budget End
1998-06-30
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Dartmouth College
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755

  Publications

Swartz, Harold M; Taie, Satoshi; Miyake, Minoru et al. (2003) The effects of anesthesia on cerebral tissue oxygen tension: use of EPR oximetry to make repeated measurements. Adv Exp Med Biol 530:569-75
Pogue, Brian W; Zhu, Haoqin; Nwaigwe, Casmair et al. (2003) Hemoglobin imaging with hybrid magnetic resonance and near-infrared diffuse tomography. Adv Exp Med Biol 530:215-24
Hou, Huagang; Grinberg, Oleg Y; Taie, Satoshi et al. (2003) Electron paramagnetic resonance assessment of brain tissue oxygen tension in anesthetized rats. Anesth Analg 96:1467-72, table of contents
Swartz, Harold M; Dunn, Jeff F (2003) Measurements of oxygen in tissues: overview and perspectives on methods. Adv Exp Med Biol 530:1-12
Nattie, Eugene; Li, Aihua; Meyerand, Elizabeth et al. (2002) Ventral medulla pHi measured in vivo by 31P NMR is not regulated during hypercapnia in anesthetized rat. Respir Physiol Neurobiol 130:139-49
Lei, H; Grinberg, O; Nwaigwe, C I et al. (2001) The effects of ketamine-xylazine anesthesia on cerebral blood flow and oxygenation observed using nuclear magnetic resonance perfusion imaging and electron paramagnetic resonance oximetry. Brain Res 913:174-9
Dunn, J F; Grinberg, O; Roche, M et al. (2000) Noninvasive assessment of cerebral oxygenation during acclimation to hypobaric hypoxia. J Cereb Blood Flow Metab 20:1632-5
Nwaigwe, C I; Roche, M A; Grinberg, O et al. (2000) Effect of hyperventilation on brain tissue oxygenation and cerebrovenous PO2 in rats. Brain Res 868:150-6
Rolett, E L; Azzawi, A; Liu, K J et al. (2000) Critical oxygen tension in rat brain: a combined (31)P-NMR and EPR oximetry study. Am J Physiol Regul Integr Comp Physiol 279:R9-R16
Dunn, J F; Nwaigwe, C I; Roche, M (1999) Measurement of arterial, venous, and interstitial pO2 during acute hypoxia in rat brain using a time-resolved luminescence-based oxygen sensor. Adv Exp Med Biol 471:43-8

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