Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA067937-02
Application #
2111749
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1995-09-30
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Zhang, F J; Cortez, C; Harvey, R G (2000) New synthetic approaches to polycyclic aromatic hydrocarbons and their carcinogenic oxidized metabolites: derivatives of benzo[s]picene, benzo[rst]pentaphene, and dibenzo[b,def]chrysene. J Org Chem 65:3952-60
Szeliga, J; Amin, S; Zhang, F J et al. (1999) Reactions of dihydrodiol epoxides of 5-methylchrysene and 5, 6-dimethylchrysene with DNA and deoxyribonucleotides. Chem Res Toxicol 12:347-52
Agarwal, R; Coffing, S L; Baird, W M et al. (1999) Metabolic activation of 4H-cyclopenta[def]chrysene in human mammary carcinoma MCF-7 cell cultures. Chem Res Toxicol 12:437-41
Jarabak, R; Harvey, R G; Jarabak, J (1998) Redox cycling of polycyclic aromatic hydrocarbon o-quinones: metal ion-catalyzed oxidation of catechols bypasses inhibition by superoxide dismutase. Chem Biol Interact 115:201-13
Burczynski, M E; Harvey, R G; Penning, T M (1998) Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione. Biochemistry 37:6781-90
Pandey, S; Fletcher, K A; Powell, J R et al. (1997) Spectrochemical investigations of fluorescence quenching agents. Part 5. Effect of surfactants of the ability of nitromethane to selectively quench fluorescence emission of alternant PAHs. Spectrochim Acta A Mol Biomol Spectrosc 53A:165-72
Baer-Dubowska, W; Vulimiri, S V; Harvey, R G et al. (1997) Analysis of 7-methylbenz[a]anthracene-DNA adducts formed in SENCAR mouse epidermis by 32P-postlabeling. Carcinogenesis 18:523-9
Jarabak, R; Harvey, R G; Jarabak, J (1997) Redox cycling of polycyclic aromatic hydrocarbon o-quinones: reversal of superoxide dismutase inhibition by ascorbate. Arch Biochem Biophys 339:92-8