Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA068028-02
Application #
2111867
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1995-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Medical College of Wisconsin
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073134603
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Chitambar, Christopher R (2012) Gallium-containing anticancer compounds. Future Med Chem 4:1257-72
Chitambar, C R; Wereley, J P; Heiman, T et al. (2000) Cellular adaptation to down-regulated iron transport into lymphoid leukaemic cells: effects on the expression of the gene for ribonucleotide reductase. Biochem J 345 Pt 3:681-5
Wong, S J; Myette, M S; Wereley, J P et al. (1999) Increased sensitivity of hydroxyurea-resistant leukemic cells to gemcitabine. Clin Cancer Res 5:439-43
Knorr, G M; Chitambar, C R (1998) Gallium-pyridoxal isonicotinoyl hydrazone (Ga-PIH), a novel cytotoxic gallium complex. A comparative study with gallium nitrate. Anticancer Res 18:1733-7
Chitambar, C R; Wereley, J P (1998) Transferrin receptor-dependent and -independent iron transport in gallium-resistant human lymphoid leukemic cells. Blood 91:4686-93
Myette, M S; Elford, H L; Chitambar, C R (1998) Interaction of gallium nitrate with other inhibitors of ribonucleotide reductase: effects on the proliferation of human leukemic cells. Cancer Lett 129:199-204
Chitambar, C R; Zahir, S A; Ritch, P S et al. (1997) Evaluation of continuous-infusion gallium nitrate and hydroxyurea in combination for the treatment of refractory non-Hodgkin's lymphoma. Am J Clin Oncol 20:173-8
Chitambar, C R; Wereley, J P (1997) Resistance to the antitumor agent gallium nitrate in human leukemic cells is associated with decreased gallium/iron uptake, increased activity of iron regulatory protein-1, and decreased ferritin production. J Biol Chem 272:12151-7
Chitambar, C R; Boon, P; Wereley, J P (1996) Evaluation of transferrin and gallium-pyridoxal isonicotinoyl hydrazone as potential therapeutic agents to overcome lymphoid leukemic cell resistance to gallium nitrate. Clin Cancer Res 2:1009-15
Drobyski, W R; Ul-Haq, R; Majewski, D et al. (1996) Modulation of in vitro and in vivo T-cell responses by transferrin-gallium and gallium nitrate. Blood 88:3056-64