Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA068239-01A1
Application #
2112136
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1996-04-05
Project End
2001-01-31
Budget Start
1996-04-05
Budget End
1997-01-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Temple University
Department
Miscellaneous
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19122
Mangan, J K; Tantravahi, R V; Rane, S G et al. (2006) Granulocyte colony-stimulating factor-induced upregulation of Jak3 transcription during granulocytic differentiation is mediated by the cooperative action of Sp1 and Stat3. Oncogene 25:2489-99
Mangan, James K; Rane, Sushil G; Kang, Anthony D et al. (2004) Mechanisms associated with IL-6-induced up-regulation of Jak3 and its role in monocytic differentiation. Blood 103:4093-101
Rane, Sushil G; Mangan, James K; Amanullah, Arshad et al. (2002) Activation of the Jak3 pathway is associated with granulocytic differentiation of myeloid precursor cells. Blood 100:2753-62
Baker, S J; Reddy, E P (2000) Cloning of murine G1RP, a novel gene related to Drosophila melanogaster g1. Gene 248:33-40
Rane, S G; Reddy, E P (2000) Janus kinases: components of multiple signaling pathways. Oncogene 19:5662-79
Baker, S J; Cosenza, S C; Reddy, E P (1998) The role of v-Fgr myristoylation and the Gag domain in membrane binding and cellular transformation. Virology 249:1-11
Oh, I H; Reddy, E P (1998) The C-terminal domain of B-Myb acts as a positive regulator of transcription and modulates its biological functions. Mol Cell Biol 18:499-511
Chaturvedi, P; Reddy, M V; Reddy, E P (1998) Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation. Oncogene 16:1749-58
Chaturvedi, P; Sharma, S; Reddy, E P (1997) Abrogation of interleukin-3 dependence of myeloid cells by the v-src oncogene requires SH2 and SH3 domains which specify activation of STATs. Mol Cell Biol 17:3295-304
Gaozza, E; Baker, S J; Vora, R K et al. (1997) AATYK: a novel tyrosine kinase induced during growth arrest and apoptosis of myeloid cells. Oncogene 15:3127-35

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