Tgf Beta Role in Colon Cancer

Willson, James K.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 5R01CA068316-02
• Application #: 2112243
• Study Section: Special Emphasis Panel (ZRG3-ET-2 (01))
• Project Start: 1995-09-06
• Project End: 1998-08-31
• Budget Start: 1996-09-01
• Budget End: 1997-08-31
• Support Year: 2
• Fiscal Year: 1996

Institution

• Name: Case Western Reserve University
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 077758407
• City: Cleveland
• State: OH
• Country: United States
• Zip Code: 44106

Publications

Awwad, Rana A; Sergina, Natalia; Yang, Haisu et al. (2003) The role of transforming growth factor alpha in determining growth factor independence. Cancer Res 63:4731-8

Venkateswarlu, Srinivas; Dawson, Dawn M; St Clair, Patricia et al. (2002) Autocrine heregulin generates growth factor independence and blocks apoptosis in colon cancer cells. Oncogene 21:78-86

Ye, S C; Foster, J M; Li, W et al. (1999) Contextual effects of transforming growth factor beta on the tumorigenicity of human colon carcinoma cells. Cancer Res 59:4725-31

Ko, Y; Banerji, S S; Liu, Y et al. (1998) Expression of transforming growth factor-beta receptor type II and tumorigenicity in human breast adenocarcinoma MCF-7 cells. J Cell Physiol 176:424-34

Ko, Y; Koli, K M; Banerji, S S et al. (1998) A kinase-defective transforming growth factor-beta receptor type II is a dominant-negative regulator for human breast carcinoma MCF-7 cells. Int J Oncol 12:87-94

Jiang, D; Yang, H; Willson, J K et al. (1998) Autocrine transforming growth factor alpha provides a growth advantage to malignant cells by facilitating re-entry into the cell cycle from suboptimal growth states. J Biol Chem 273:31471-9