Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA068494-01A1
Application #
2112474
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1996-09-01
Project End
2000-06-30
Budget Start
1996-09-01
Budget End
1997-06-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Arkansas for Medical Sciences
Department
Pathology
Type
Schools of Medicine
DUNS #
City
Little Rock
State
AR
Country
United States
Zip Code
72205
Reigle, Kristin L; Di Lullo, Gloria; Turner, Kevin R et al. (2008) Non-enzymatic glycation of type I collagen diminishes collagen-proteoglycan binding and weakens cell adhesion. J Cell Biochem 104:1684-98
Langford, J Kevin; Yang, Yang; Kieber-Emmons, Thomas et al. (2005) Identification of an invasion regulatory domain within the core protein of syndecan-1. J Biol Chem 280:3467-73
Sanderson, Ralph D; Yang, Yang; Kelly, Thomas et al. (2005) Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: growth regulation and the prospect of new cancer therapies. J Cell Biochem 96:897-905
Kelly, Thomas; Suva, Larry J; Huang, Yan et al. (2005) Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases. Cancer Res 65:5778-84
Dai, Yuemeng; Yang, Yang; MacLeod, Veronica et al. (2005) HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo. J Biol Chem 280:40066-73
Sanderson, Ralph D; Yang, Yang; Suva, Larry J et al. (2004) Heparan sulfate proteoglycans and heparanase--partners in osteolytic tumor growth and metastasis. Matrix Biol 23:341-52
Reiland, Jane; Sanderson, Ralph D; Waguespack, Marian et al. (2004) Heparanase degrades syndecan-1 and perlecan heparan sulfate: functional implications for tumor cell invasion. J Biol Chem 279:8047-55
Kelly, Thomas; Miao, Hua-Quan; Yang, Yang et al. (2003) High heparanase activity in multiple myeloma is associated with elevated microvessel density. Cancer Res 63:8749-56
Bayer-Garner, Ilene B; Joseph, Lija; Sanderson, Ralph D et al. (2003) Expression of syndecan-1 is a sensitive marker for cutaneous plasmacytoma. J Cutan Pathol 30:18-22
Wilkins-Port, Cynthia E; Sanderson, Ralph D; Tominna-Sebald, Eiman et al. (2003) Vitronectin's basic domain is a syndecan ligand which functions in trans to regulate vitronectin turnover. Cell Commun Adhes 10:85-103

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