Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA068498-02
Application #
2112481
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1995-09-30
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
New York University
Department
Pathology
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10016
Jamieson, Kelly V; Hubbard, Stevan R; Meruelo, Daniel (2011) Structure-guided identification of a laminin binding site on the laminin receptor precursor. J Mol Biol 405:24-32
Tseng, J-C; Granot, T; DiGiacomo, V et al. (2010) Enhanced specific delivery and targeting of oncolytic Sindbis viral vectors by modulating vascular leakiness in tumor. Cancer Gene Ther 17:244-55
Tseng, J-C; Daniels, G; Meruelo, D (2009) Controlled propagation of replication-competent Sindbis viral vector using suicide gene strategy. Gene Ther 16:291-6
Jamieson, Kelly V; Wu, Jinhua; Hubbard, Stevan R et al. (2008) Crystal structure of the human laminin receptor precursor. J Biol Chem 283:3002-5
Tseng, J-C; Zheng, Y; Yee, H et al. (2007) Restricted tissue tropism and acquired resistance to Sindbis viral vector expression in the absence of innate and adaptive immunity. Gene Ther 14:1166-74
Tseng, Jen-Chieh; Zanzonico, Pat B; Levin, Brandi et al. (2006) Tumor-specific in vivo transfection with HSV-1 thymidine kinase gene using a Sindbis viral vector as a basis for prodrug ganciclovir activation and PET. J Nucl Med 47:1136-43
Hurtado, Alicia; Tseng, Jen-Chieh; Meruelo, Daniel (2006) Gene therapy that safely targets and kills tumor cells throughout the body. Rejuvenation Res 9:36-44
Hurtado, Alicia; Tseng, Jen-Chieh; Boivin, Christopher et al. (2005) Identification of amino acids of Sindbis virus E2 protein involved in targeting tumor metastases in vivo. Mol Ther 12:813-23
Tseng, Jen-Chieh; Hurtado, Alicia; Yee, Herman et al. (2004) Using sindbis viral vectors for specific detection and suppression of advanced ovarian cancer in animal models. Cancer Res 64:6684-92
Tseng, Jen-Chieh; Levin, Brandi; Hurtado, Alicia et al. (2004) Systemic tumor targeting and killing by Sindbis viral vectors. Nat Biotechnol 22:70-7

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