Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA068615-01A1
Application #
2112620
Study Section
Reproductive Endocrinology Study Section (REN)
Project Start
1996-08-01
Project End
2000-05-31
Budget Start
1996-08-01
Budget End
1997-05-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Urology
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
Lamb, Dolores J; Puxeddu, Efisio; Malik, Nusrat et al. (2003) Molecular analysis of the androgen receptor in ten prostate cancer specimens obtained before and after androgen ablation. J Androl 24:215-25
James, Alaina J; Agoulnik, Irina U; Harris, Jonathan M et al. (2002) A novel androgen receptor mutant, A748T, exhibits hormone concentration-dependent defects in nuclear accumulation and activity despite normal hormone-binding affinity. Mol Endocrinol 16:2692-705
Casella, R; Maduro, M R; Lipshultz, L I et al. (2001) Significance of the polyglutamine tract polymorphism in the androgen receptor. Urology 58:651-6
Marcelli, M; Ittmann, M; Mariani, S et al. (2000) Androgen receptor mutations in prostate cancer. Cancer Res 60:944-9
Stenoien, D L; Cummings, C J; Adams, H P et al. (1999) Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone. Hum Mol Genet 8:731-41
Nazareth, L V; Stenoien, D L; Bingman 3rd, W E et al. (1999) A C619Y mutation in the human androgen receptor causes inactivation and mislocalization of the receptor with concomitant sequestration of SRC-1 (steroid receptor coactivator 1) Mol Endocrinol 13:2065-75
Marcelli, M; Cunningham, G R (1999) Hormonal signaling in prostatic hyperplasia and neoplasia. J Clin Endocrinol Metab 84:3463-8
Klein, K A; Reiter, R E; Redula, J et al. (1997) Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice. Nat Med 3:402-8