Specific Aims and Hypotheses: The objective of this project is to develop an imaging module for full size digital x-ray mammography. We propose to explore a CCD imaging technique using a novel area-scanning, radiation- shielding mechanism. The concept uses a 6x8 mosaic of CCD imagers. These CCDs are mounted on a carrier platform with gaps between their active areas that are exactly 15 mm in width. The platform is placed under a standard mammographic unit. A lead filter is interposed between the x-ray source and the patient. The lead filter has a mosaic of CCDs and is moved in synchronism with the CCDs. To provide a complete and contiguous image the mosaic will actually be repositioned three times, and a total of four x-ray exposures is made. The unique features of the proposed technique are: large field coverage (18 cm x 24 cm), high spatial resolution (16 lp/mm to 18 lp/mm), scatter rejection and excellent contrast characteristics and lesion detectability under clinical conditions. Methods and Experiments: The proposed imaging concept is unique because its novel optical configuration and scanning-sampling method differs significantly from existing techniques. In order to test our hypotheses, we propose to build a laboratory system to measure modulation transfer function, signal-to-noise ratio, detective quantum efficiency, and lesion detectability. We also propose to conduct phantom studies. Based on our preliminary experiments, a dose efficient, x-ray quantum noise limited system will be achieved using the proposed CCD imaging module. The lesion detectability of this digital mammographic technique is comparable to the gold standard of screen-film technique under the same conditions.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Project (R01)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG7-DMG (01))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Virginia
Schools of Medicine
United States
Zip Code
Chen, Wei R; Korbelik, Mladen; Bartels, Kenneth E et al. (2005) Enhancement of laser cancer treatment by a chitosan-derived immunoadjuvant. Photochem Photobiol 81:190-5
Jiang, Hangyi; Chen, Wei R; Liu, Hong (2002) Techniques to improve the accuracy and to reduce the variance in noise power spectrum measurement. IEEE Trans Biomed Eng 49:1270-8
Li, Yuhua; Chen, Wei R; Zhang, Yimo et al. (2002) Comparison of analog and digital Fourier transforms in medical image analysis. J Biomed Opt 7:255-61
Jiang, H; Chen, W R; Wang, G et al. (2001) Localization error analysis for stereo X-ray image guidance with probability method. Med Eng Phys 23:573-81
Chen, W R; Singhal, A K; Liu, H et al. (2001) Antitumor immunity induced by laser immunotherapy and its adoptive transfer. Cancer Res 61:459-61
Liu, H; Wang, G (2000) Design of a dual CCD configuration to improve the signal-to-noise ratio. Med Phys 27:2435-7
Jiang, H; Liu, H; Wang, G et al. (2000) A localization algorithm and error analysis for stereo x-ray image guidance. Med Phys 27:885-93
Liu, H; Wang, G; Chen, J et al. (1999) Interpolation algorithms for digital mammography systems with multiple detectors. Acad Radiol 6:170-5
Liu, H; Xu, J; Fajardo, L L (1999) Optical processing architecture and its potential application for digital and analog radiography. Med Phys 26:648-52
Xu, F; Liu, H; Wu, X et al. (1999) Measurement of x-ray attenuation coefficients of aqueous solutions of indocyanine green and glycated chitosan. Med Phys 26:1371-4

Showing the most recent 10 out of 14 publications