Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA069056-09
Application #
6763162
Study Section
Metabolic Pathology Study Section (MEP)
Program Officer
Kim, Young Shin
Project Start
1996-07-01
Project End
2006-06-30
Budget Start
2004-07-01
Budget End
2006-06-30
Support Year
9
Fiscal Year
2004
Total Cost
$304,560
Indirect Cost

  Institution

Name
University of California Berkeley
Department
Nutrition
Type
Schools of Earth Sciences/Natur
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704

  Publications

Nicastro, Holly L; Firestone, Gary L; Bjeldanes, Leonard F (2013) 3,3'-diindolylmethane rapidly and selectively inhibits hepatocyte growth factor/c-Met signaling in breast cancer cells. J Nutr Biochem 24:1882-8
Vivar, Omar I; Saunier, Elise F; Leitman, Dale C et al. (2010) Selective activation of estrogen receptor-beta target genes by 3,3'-diindolylmethane. Endocrinology 151:1662-7
Vivar, Omar I; Lin, Chia-Lei; Firestone, Gary L et al. (2009) 3,3'-Diindolylmethane induces a G(1) arrest in human prostate cancer cells irrespective of androgen receptor and p53 status. Biochem Pharmacol 78:469-76
Xue, Ling; Pestka, James J; Li, Maoxiang et al. (2008) 3,3'-Diindolylmethane stimulates murine immune function in vitro and in vivo. J Nutr Biochem 19:336-44
Riby, Jacques E; Firestone, Gary L; Bjeldanes, Leonard F (2008) 3,3'-diindolylmethane reduces levels of HIF-1alpha and HIF-1 activity in hypoxic cultured human cancer cells. Biochem Pharmacol 75:1858-67
Gong, Yixuan; Sohn, Heesook; Xue, Ling et al. (2006) 3,3'-Diindolylmethane is a novel mitochondrial H(+)-ATP synthase inhibitor that can induce p21(Cip1/Waf1) expression by induction of oxidative stress in human breast cancer cells. Cancer Res 66:4880-7
Riby, Jacques E; Xue, Ling; Chatterji, Urmi et al. (2006) Activation and potentiation of interferon-gamma signaling by 3,3'-diindolylmethane in MCF-7 breast cancer cells. Mol Pharmacol 69:430-9
Gong, Yixuan; Firestone, Gary L; Bjeldanes, Leonard F (2006) 3,3'-diindolylmethane is a novel topoisomerase IIalpha catalytic inhibitor that induces S-phase retardation and mitotic delay in human hepatoma HepG2 cells. Mol Pharmacol 69:1320-7
Chang, Xiaofei; Firestone, Gary L; Bjeldanes, Leonard F (2006) Inhibition of growth factor-induced Ras signaling in vascular endothelial cells and angiogenesis by 3,3'-diindolylmethane. Carcinogenesis 27:541-50
Staub, Richard E; Onisko, Bruce; Bjeldanes, Leonard F (2006) Fate of 3,3'-diindolylmethane in cultured MCF-7 human breast cancer cells. Chem Res Toxicol 19:436-42

Showing the most recent 10 out of 28 publications