The purpose of the project described in this application is to analyze structural bases of B7:CD28/CTLA4 interactions and respective function of CD28 and CTLA4 in late phase of immune responses, namely clonal expansion and effector function of activated T cells. Specifically the following issues will be addressed: 1) Structural basis of B7:CD28/CTLA4 interaction. 2) The possibility of transduction of opposing biological signals by CD28 and CTLA4. 3) The effector function in anti-tumor immunity through the identification of the receptor involved in rejecting B7-bearing tumors in vivo and cytolysis of B7-bearing tumors in vitro. The experiments will employ site directed mutagenesis of B7-1 and the use of CD28 KO mice.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA069091-02
Application #
2414428
Study Section
Experimental Immunology Study Section (EI)
Project Start
1996-07-01
Project End
2000-04-30
Budget Start
1997-05-01
Budget End
1998-04-30
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
New York University
Department
Pathology
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10016
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