It is generally accepted that the genetic background is a determining factor in the response of individuals to environmental carcinogens and the importance of genetic factors in chemical carcinogens has been well established in several animal models. In the mouse skin carcinogenesis system, studies from different laboratories have shown that genetic susceptibility affects the initiation and promotion phases of carcinogenesis. Based on recent preliminary results from our laboratory, we postulate that tumor progression in the mouse skin model (i.e., the ability of papillomas to develop premalignant changes and convert to squamous cell carcinomas) is genetically regulated by modifier genes which are independent of the genes conferring susceptibility to tumor promotion. The long term objective of this project is to establish a genetic model for the susceptibility to tumor progression in the mouse skin and to identify the putative progression susceptibility genes.
The specific aims of this proposal are: 1) To establish a genetic model of tumor progression susceptibility using F1,F2 between SENCAR derived mouse strains. 2) To map tumor progression susceptibility genes, using the F2 and backcrosses of specific aim 1 and microsatellite markers. 3) To investigate phenotypic differences between SSIN and SENCAR B/pt that can provide clues for the differential progression of the papilloma.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA069146-03
Application #
2871874
Study Section
Metabolic Pathology Study Section (MEP)
Program Officer
Okano, Paul
Project Start
1997-04-15
Project End
2001-01-31
Budget Start
1999-02-01
Budget End
2000-01-31
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Internal Medicine/Medicine
Type
Organized Research Units
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030
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