Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA070134-01
Application #
2114084
Study Section
Special Emphasis Panel (ZRG2-IMB (02))
Project Start
1996-06-01
Project End
2000-03-31
Budget Start
1996-06-01
Budget End
1997-03-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Pathology
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
Johansson, Maria H; Taylor, Mesha A; Jagodic, Maja et al. (2006) Mapping of quantitative trait loci determining NK cell-mediated resistance to MHC class I-deficient bone marrow grafts in perforin-deficient mice. J Immunol 177:7923-9
Koh, Crystal Y; Raziuddin, Arati; Welniak, Lisbeth A et al. (2002) NK inhibitory-receptor blockade for purging of leukemia: effects on hematopoietic reconstitution. Biol Blood Marrow Transplant 8:17-25
Taylor, Mesha Austin; Ward, Brant; Schatzle, John D et al. (2002) Perforin- and Fas-dependent mechanisms of natural killer cell-mediated rejection of incompatible bone marrow cell grafts. Eur J Immunol 32:793-9
Morris, Margaret A; Liu, Jingxuan; Arora, Veera et al. (2002) B6 strain Ly49I inhibitory gene expression on T cells in FVB.Ly49IB6 transgenic mice fails to prevent normal T cell functions. J Immunol 169:3661-6
Morris, Margaret A; Koulich, Elena; Liu, Jingxuan et al. (2002) Definition of additional functional ligands for Ly49I(B6) using FVBLy49I(B6) transgenic mice and B6 natural killer cell effectors. Transplantation 74:1449-54
Murphy, W J; Koh, C Y; Raziuddin, A et al. (2001) Immunobiology of natural killer cells and bone marrow transplantation: merging of basic and preclinical studies. Immunol Rev 181:279-89
Koh, C Y; Blazar, B R; George, T et al. (2001) Augmentation of antitumor effects by NK cell inhibitory receptor blockade in vitro and in vivo. Blood 97:3132-7
Taylor, M A; Chaudhary, P M; Klem, J et al. (2001) Inhibition of the death receptor pathway by cFLIP confers partial engraftment of MHC class I-deficient stem cells and reduces tumor clearance in perforin-deficient mice. J Immunol 167:4230-7
Austin Taylor, M; Bennett, M; Kumar, V et al. (2000) Functional defects of NK cells treated with chloroquine mimic the lytic defects observed in perforin-deficient mice. J Immunol 165:5048-53
Liu, J; Morris, M A; Nguyen, P et al. (2000) Ly49I NK cell receptor transgene inhibition of rejection of H2b mouse bone marrow transplants. J Immunol 164:1793-9