Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA070331-01
Application #
2114239
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1996-05-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Princeton University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
002484665
City
Princeton
State
NJ
Country
United States
Zip Code
08544
Hindley, Alison D; Park, Sungdae; Wang, Lily et al. (2004) Engineering the serine/threonine protein kinase Raf-1 to utilise an orthogonal analogue of ATP substituted at the N6 position. FEBS Lett 556:26-34
Liu, Ying; Kung, Charles; Fishburn, James et al. (2004) Two cyclin-dependent kinases promote RNA polymerase II transcription and formation of the scaffold complex. Mol Cell Biol 24:1721-35
Ulrich, Scott M; Kenski, Denise M; Shokat, Kevan M (2003) Engineering a ""methionine clamp"" into Src family kinases enhances specificity toward unnatural ATP analogues. Biochemistry 42:7915-21
Fan, Qi-Wen; Specht, Kimberly Musa; Zhang, Chao et al. (2003) Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach. Cancer Res 63:8930-8
Buzko, Oleksandr V; Bishop, Anthony C; Shokat, Kevan M (2002) Modified AutoDock for accurate docking of protein kinase inhibitors. J Comput Aided Mol Des 16:113-27
Witucki, Laurie A; Huang, Xin; Shah, Kavita et al. (2002) Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme. Chem Biol 9:25-33
Kraybill, Brian C; Elkin, Lisa L; Blethrow, Justin D et al. (2002) Inhibitor scaffolds as new allele specific kinase substrates. J Am Chem Soc 124:12118-28
Shah, Kavita; Shokat, Kevan M (2002) A chemical genetic screen for direct v-Src substrates reveals ordered assembly of a retrograde signaling pathway. Chem Biol 9:35-47
Holt, Jeffrey R; Gillespie, Susan K H; Provance, D William et al. (2002) A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells. Cell 108:371-81
Alaimo, P J; Shogren-Knaak, M A; Shokat, K M (2001) Chemical genetic approaches for the elucidation of signaling pathways. Curr Opin Chem Biol 5:360-7

Showing the most recent 10 out of 21 publications