Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA071079-02S1
Application #
2653186
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1996-07-15
Project End
1999-06-30
Budget Start
1997-07-01
Budget End
1998-06-30
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Maryland Balt CO Campus
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21250
Zhang, Ning; Chen, Huan-Ming; Sood, Ramesh et al. (2002) in vitro inhibition of the measles virus by novel ring-expanded ('fat') nucleoside analogues containing the imidazo[4,5-e]diazepine ring system. Bioorg Med Chem Lett 12:3391-4
Hosmane, Ramachandra S (2002) Ring-expanded (""Fat"") nucleosides as broad-spectrum anticancer and antiviral agents. Curr Top Med Chem 2:1093-109
Borowski, Peter; Lang, Melanie; Haag, Annemarie et al. (2002) Characterization of imidazo[4,5-d]pyridazine nucleosides as modulators of unwinding reaction mediated by West Nile virus nucleoside triphosphatase/helicase: evidence for activity on the level of substrate and/or enzyme. Antimicrob Agents Chemother 46:1231-9
Sood, Ramesh K; Bhadti, Vishweshwar S; Fattom, Ali I et al. (2002) Novel ring-expanded nucleoside analogs exhibit potent and selective inhibition of hepatitis B virus replication in cultured human hepatoblastoma cells. Antiviral Res 53:159-64
Chen, H M; Hosmane, R S (2001) Acyclic nucleoside/nucleotide analogues with an imidazole ring skeleton. Nucleosides Nucleotides Nucleic Acids 20:1599-614
Gill, J K; Wang, L; Bretner, M et al. (2001) Potent in vitro anticancer activities of ring-expanded (""fat"") nucleosides containing the imidazo[4,5-e][1,3]diazepine ring system. Nucleosides Nucleotides Nucleic Acids 20:1043-5
Wang, L; Hosmane, R S (2001) A unique ring-expanded acyclic nucleoside analogue that inhibits both adenosine deaminase (ADA) and guanine deaminase (GDA; guanase): synthesis and enzyme inhibition studies of 4,6-diamino-8H-1-hydroxyethoxymethyl-8-iminoimidazo[4,5-e][1,3]diazepine. Bioorg Med Chem Lett 11:2893-6
Bretner, M; Beckett, D; Hosmane, R S (1999) Potent anti-hepatitis B viral activity and inhibition of bacteriophage T7 RNA polymerase by a ""fat"" nucleoside and its 5'-triphosphate derivative: synthetic, biochemical, and biological studies of 4,8-diamino-6-imino-6H-1-beta-D-ribofuranosyl-imidazo[4, Nucleosides Nucleotides 18:837-8
Chen, H M; Sood, R; Hosmane, R S (1999) An efficient, short synthesis and potent anti-hepatitis B viral activity of a novel ring-expanded purine nucleoside analogue containing a 5:7-fused, planar, aromatic, imidazo[4,5-e][1,3]diazepine ring system. Nucleosides Nucleotides 18:331-5
Rajappan, V P; Hosmane, R S (1999) Investigations into biochemical mode of inhibition of guanase by azepinomycin: synthesis and biochemical screening of several analogues of azepinomycin. Nucleosides Nucleotides 18:835-6

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