Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA071704-01
Application #
2115262
Study Section
Experimental Virology Study Section (EVR)
Project Start
1996-08-01
Project End
2001-05-31
Budget Start
1996-08-01
Budget End
1997-05-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Saint Louis University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
Saint Louis
State
MO
Country
United States
Zip Code
63103

  Publications

Kuppuswamy, M; Spencer, J F; Doronin, K et al. (2005) Oncolytic adenovirus that overproduces ADP and replicates selectively in tumors due to hTERT promoter-regulated E4 gene expression. Gene Ther 12:1608-17
Toth, Karoly; Spencer, Jacqueline F; Tollefson, Ann E et al. (2005) Cotton rat tumor model for the evaluation of oncolytic adenoviruses. Hum Gene Ther 16:139-46
Toth, Karoly; Djeha, Hakim; Ying, Baoling et al. (2004) An oncolytic adenovirus vector combining enhanced cell-to-cell spreading, mediated by the ADP cytolytic protein, with selective replication in cancer cells with deregulated wnt signaling. Cancer Res 64:3638-44
Ying, Baoling; Wold, William S M (2003) Adenovirus ADP protein (E3-11.6K), which is required for efficient cell lysis and virus release, interacts with human MAD2B. Virology 313:224-34
Tollefson, Ann E; Scaria, Abraham; Ying, Baoling et al. (2003) Mutations within the ADP (E3-11.6K) protein alter processing and localization of ADP and the kinetics of cell lysis of adenovirus-infected cells. J Virol 77:7764-78
Doronin, Konstantin; Toth, Karoly; Kuppuswamy, Mohan et al. (2003) Overexpression of the ADP (E3-11.6K) protein increases cell lysis and spread of adenovirus. Virology 305:378-87
Toth, Karoly; Tarakanova, Vera; Doronin, Konstantin et al. (2003) Radiation increases the activity of oncolytic adenovirus cancer gene therapy vectors that overexpress the ADP (E3-11.6K) protein. Cancer Gene Ther 10:193-200
Habib, Nagy A; Mitry, Ragai; Seth, Prem et al. (2002) Adenovirus replication-competent vectors (KD1, KD3) complement the cytotoxicity and transgene expression from replication-defective vectors (Ad-GFP, Ad-Luc). Cancer Gene Ther 9:651-4
Doronin, K; Kuppuswamy, M; Toth, K et al. (2001) Tissue-specific, tumor-selective, replication-competent adenovirus vector for cancer gene therapy. J Virol 75:3314-24
Doronin, K; Toth, K; Kuppuswamy, M et al. (2000) Tumor-specific, replication-competent adenovirus vectors overexpressing the adenovirus death protein. J Virol 74:6147-55

Showing the most recent 10 out of 12 publications