The applicants proposed to investigate breast imaging based on the novel ultrasound-modulated optical tomography technique to provide a non-invasive, nonionizing, inexpensive diagnostic tool for early breast cancer detection. A focused ultrasonic wave defines the imaging resolution and overcomes the poor localization of light in biological tissues caused by the strong scattering of light in tissues. The ultrasound-modulated optical signal of the tumors has the potential for early detection of breast cancers and for assessing and monitoring treatment, because optical properties are related to tissue constituents and their molecular conformations. Recent studies have demonstrated that objects buried in dense turbid media (such as biological tissues) can be imaged using ultrasound-modulated optical tomography. Ultrasound focused into the tissue modulates the laser light passing through the focal spot. The ultrasound-modulated optical signal reflects the local mechanical and optical properties at the focal spot. Buried objects are located by scanning the device and detecting alterations of the ultrasound-modulated optical signal. So far, the applicants have achieved 1-mm imaging resolution in a 5-cm thick tissue phantom. This research has indicated the potential for clinical application in breast imaging and cancer detection. The differences in mechanical and optical properties between normal and abnormal tissues will be the basis of detecting tumors using this technique. To improve the imaging quality of single-frequency ultrasound-modulated optical images, the applicants have designed a refined imaging technique: frequency-swept ultrasound-modulated optical tomography, which minimizes the interference originating from off the ultrasonic focus.
The specific aims of the proposed studies on frequency-swept ultrasound-modulate optical tomography include: 1.) Imaging objects in tissue phantoms; 2.) Imaging tumors in biological tissue in vitro; and 3.) Imaging breast tumors in vivo and measuring hemoglobin oxygenation saturation of tumors.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA071980-02
Application #
2700703
Study Section
Special Emphasis Panel (ZRG7-DMG (01))
Program Officer
Menkens, Anne E
Project Start
1997-05-15
Project End
2000-04-30
Budget Start
1998-05-01
Budget End
1999-04-30
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Texas Engineering Experiment Station
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
847205572
City
College Station
State
TX
Country
United States
Zip Code
77845
Yao, Gang; Wang, Lihong V (2004) Signal dependence and noise source in ultrasound-modulated optical tomography. Appl Opt 43:1320-6
Garcia-Uribe, Alejandro; Kehtarnavaz, Nasser; Marquez, Guillermo et al. (2004) Skin cancer detection by spectroscopic oblique-incidence reflectometry: classification and physiological origins. Appl Opt 43:2643-50
Wang, Xueding; Wang, Lihong V; Sun, Chia-Wei et al. (2003) Polarized light propagation through scattering media: time-resolved Monte Carlo simulations and experiments. J Biomed Opt 8:608-17
Xu, Yuan; Wang, Lihong V (2003) Effects of acoustic heterogeneity in breast thermoacoustic tomography. IEEE Trans Ultrason Ferroelectr Freq Control 50:1134-46
Wang, Lihong V (2003) Ultrasound-mediated biophotonic imaging: a review of acousto-optical tomography and photo-acoustic tomography. Dis Markers 19:123-38
Xu, Minghua; Xu, Yuan; Wang, Lihong V (2003) Time-domain reconstruction algorithms and numerical simulations for thermoacoustic tomography in various geometries. IEEE Trans Biomed Eng 50:1086-99
Xu, Yuan; Feng, Dazi; Wang, Lihong V (2002) Exact frequency-domain reconstruction for thermoacoustic tomography--I: Planar geometry. IEEE Trans Med Imaging 21:823-8
Li, Jun; Ku, Geng; Wang, Lihong V (2002) Ultrasound-modulated optical tomography of biological tissue by use of contrast of laser speckles. Appl Opt 41:6030-5
Li, Hui; Wang, Lihong V (2002) Autocorrelation of scattered laser light for ultrasound-modulated optical tomography in dense turbid media. Appl Opt 41:4739-42
Xu, Minghua; Wang, Lihong V (2002) Time-domain reconstruction for thermoacoustic tomography in a spherical geometry. IEEE Trans Med Imaging 21:814-22

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