Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA071993-01
Application #
2115480
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1996-07-25
Project End
2000-04-30
Budget Start
1996-07-25
Budget End
1997-04-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Other Basic Sciences
Type
Schools of Public Health
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Shao, Gang; Kautz, Roger; Peng, Shiqi et al. (2007) Calibration by NMR for quantitative analysis: p-toluenesulfonic acid as a reference substance. J Chromatogr A 1138:305-8
Sung, Jung-Suk; Demple, Bruce (2006) Analysis of base excision DNA repair of the oxidative lesion 2-deoxyribonolactone and the formation of DNA-protein cross-links. Methods Enzymol 408:48-64
Shimelis, Olga; Giese, Roger W (2006) Nuclease P1 digestion/high-performance liquid chromatography, a practical method for DNA quantitation. J Chromatogr A 1117:132-6
Chowdhury, Dipanjan; Beresford, Paul J; Zhu, Pengcheng et al. (2006) The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death. Mol Cell 23:133-42
Sung, Jung-Suk; DeMott, Michael S; Demple, Bruce (2005) Long-patch base excision DNA repair of 2-deoxyribonolactone prevents the formation of DNA-protein cross-links with DNA polymerase beta. J Biol Chem 280:39095-103
Demple, Bruce; Sung, Jung-Suk (2005) Molecular and biological roles of Ape1 protein in mammalian base excision repair. DNA Repair (Amst) 4:1442-9
Fung, Hua; Demple, Bruce (2005) A vital role for Ape1/Ref1 protein in repairing spontaneous DNA damage in human cells. Mol Cell 17:463-70
Shao, Gang; Giese, Roger W (2004) Trace detection of glycolic acid by electrophore labeling gas chromatography-electron capture mass spectrometry. Anal Chem 76:3049-54
Shimelis, Olga; Zhou, Xiaojuan; Li, Guodong et al. (2004) Phenolic extraction of DNA from mammalian tissues and conversion to deoxyribonucleoside-5'-monophosphates devoid of ribonucleotides. J Chromatogr A 1053:143-9
Wong, Donny; Demple, Bruce (2004) Modulation of the 5'-deoxyribose-5-phosphate lyase and DNA synthesis activities of mammalian DNA polymerase beta by apurinic/apyrimidinic endonuclease 1. J Biol Chem 279:25268-75

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