Abstract

Pregnancy and lactation early in life are associated with a reduced risk of human breast cancer, while pseudopregnancy induced by human chorionic gonadotropin (hCG) has a protective effect against mammary tumorigenesis in rats. The applicant hypothesizes that, by an enhanced gap junction intercellular communication during lactation, the normal mammary epithelial cells can effectively exert influence on a few transformed or premalignant cells. In this application the applicant proposes [Aim 1] that enhanced cell-cell communication induced by hCG modulates genetic alterations in rat mammary glands exposed to NMU; and [Aim II] that enhanced cell-cell communication modulates the genetic alterations in MCF-10 cells and comma-ID cells.
In Aim III, he will investigate the transcriptional regulation of the human Cx26 gene by lactogenic hormones or other modulation agents.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA072044-04
Application #
2895704
Study Section
Metabolic Pathology Study Section (MEP)
Program Officer
Mohla, Suresh
Project Start
1996-09-17
Project End
2000-12-31
Budget Start
1999-07-01
Budget End
2000-12-31
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455