Abstract

description) First full term pregnancy during the teen age years in women can permanently reduce their risk for developing breast cancer. In the current proposal, the investigator will thoroughly analyze the causes of parity-related refractoriness to mammary cancer development in rats, and examine the mechanism underlying the protection effect of perphenazine, a drug which causes transient prolactinemia. The proposal includes four Specific Aims: [1] Studies of the refractoriness of parous rats to MNU-induced mammary carcinogenesis, [2] whether the refractoriness is permanent, [3] characterize the perphenazine-induced refractoriness, and [4] the mechanism underlying the perphenazine-induced refractoriness. The long-term goal is to generate an experimental paradigm that can be used to develop strategies for the prevention of human breast cancer without significant alterations in the quality of life.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA072598-03
Application #
2871907
Study Section
Reproductive Endocrinology Study Section (REN)
Program Officer
Yang, Shen K
Project Start
1997-04-01
Project End
2002-01-31
Budget Start
1999-02-01
Budget End
2000-01-31
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of California Berkeley
Department
Internal Medicine/Medicine
Type
Schools of Arts and Sciences
DUNS #
094878337
City
Berkeley
State
CA
Country
United States
Zip Code
94704

  Publications

Ho, Alan L; Grewal, Ravinder K; Leboeuf, Rebecca et al. (2013) Selumetinib-enhanced radioiodine uptake in advanced thyroid cancer. N Engl J Med 368:623-32
Montero-Conde, Cristina; Ruiz-Llorente, Sergio; Dominguez, Jose M et al. (2013) Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF-mutant thyroid carcinomas. Cancer Discov 3:520-33
Thordarson, Gudmundur; Semaan, Sheila; Low, Caroline et al. (2004) Mammary tumorigenesis in growth hormone deficient spontaneous dwarf rats; effects of hormonal treatments. Breast Cancer Res Treat 87:277-90
Thordarson, Gudmundur; Slusher, Nicole; Leong, Harriet et al. (2004) Insulin-like growth factor (IGF)-I obliterates the pregnancy-associated protection against mammary carcinogenesis in rats: evidence that IGF-I enhances cancer progression through estrogen receptor-alpha activation via the mitogen-activated protein kinase Breast Cancer Res 6:R423-36
Shyamala, G; Chou, Y-C; Louie, S G et al. (2002) Cellular expression of estrogen and progesterone receptors in mammary glands: regulation by hormones, development and aging. J Steroid Biochem Mol Biol 80:137-48
Thordarson, G; Lee, A V; McCarty, M et al. (2001) Growth and characterization of N-methyl-N-nitrosourea-induced mammary tumors in intact and ovariectomized rats. Carcinogenesis 22:2039-47
Chiou, S; Yoo, J; Loh, K C et al. (2001) Identification of rat mammary tumor-1 gene (RMT-1), which is highly expressed in rat mammary tumors. Cancer Lett 174:45-55
Thordarson, G; Van Horn, K; Guzman, R C et al. (2001) Parous rats regain high susceptibility to chemically induced mammary cancer after treatment with various mammotropic hormones. Carcinogenesis 22:1027-33
Rajkumar, L; Guzman, R C; Yang, J et al. (2001) Short-term exposure to pregnancy levels of estrogen prevents mammary carcinogenesis. Proc Natl Acad Sci U S A 98:11755-9
Yang, J; Yoshizawa, K; Nandi, S et al. (1999) Protective effects of pregnancy and lactation against N-methyl-N-nitrosourea-induced mammary carcinomas in female Lewis rats. Carcinogenesis 20:623-8