Molecular Mechanism of Cell Cycle Arrest by Apigenin

Pelling, Jill C.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 1R01CA072987-01
• Application #: 2115724
• Study Section: Chemical Pathology Study Section (CPA)
• Project Start: 1996-05-01
• Project End: 2000-02-29
• Budget Start: 1996-05-01
• Budget End: 1997-02-28
• Support Year: 1
• Fiscal Year: 1996

Institution

• Name: University of Kansas
• Department: Family Medicine
• Type: Schools of Medicine
• DUNS #: 016060860
• City: Kansas City
• State: KS
• Country: United States
• Zip Code: 66160

Publications

Tong, Xin; Pelling, Jill C (2009) Enhancement of p53 expression in keratinocytes by the bioflavonoid apigenin is associated with RNA-binding protein HuR. Mol Carcinog 48:118-29

Abu-Yousif, Adnan O; Smith, Kimberly A; Getsios, Spiro et al. (2008) Enhancement of UVB-induced apoptosis by apigenin in human keratinocytes and organotypic keratinocyte cultures. Cancer Res 68:3057-65

Kanski, Jaroslaw; Hong, Sung J; Schoneich, Christian (2005) Proteomic analysis of protein nitration in aging skeletal muscle and identification of nitrotyrosine-containing sequences in vivo by nanoelectrospray ionization tandem mass spectrometry. J Biol Chem 280:24261-6

Kanski, Jaroslaw; Schoneich, Christian (2005) Protein nitration in biological aging: proteomic and tandem mass spectrometric characterization of nitrated sites. Methods Enzymol 396:160-71

Kanski, Jaroslaw; Behring, Antje; Pelling, Jill et al. (2005) Proteomic identification of 3-nitrotyrosine-containing rat cardiac proteins: effects of biological aging. Am J Physiol Heart Circ Physiol 288:H371-81

Van Dross, Rukiyah T; Hong, Xiaoman; Pelling, Jill C (2005) Inhibition of TPA-induced cyclooxygenase-2 (COX-2) expression by apigenin through downregulation of Akt signal transduction in human keratinocytes. Mol Carcinog 44:83-91

Nauser, Thomas; Koppenol, Willem H; Pelling, Jill et al. (2004) UV photolysis of 3-nitrotyrosine generates highly oxidizing species: a potential source of photooxidative stress. Chem Res Toxicol 17:1227-35

Nauser, Thomas; Pelling, Jill; Schoneich, Christian (2004) Thiyl radical reaction with amino acid side chains: rate constants for hydrogen transfer and relevance for posttranslational protein modification. Chem Res Toxicol 17:1323-8

Yamaguchi, Tamio; Nagao, Shizuko; Wallace, Darren P et al. (2003) Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys. Kidney Int 63:1983-94

Van Dross, Rukiyah; Xue, Yue; Knudson, Alexandra et al. (2003) The chemopreventive bioflavonoid apigenin modulates signal transduction pathways in keratinocyte and colon carcinoma cell lines. J Nutr 133:3800S-3804S