Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA073212-12
Application #
2895819
Study Section
Hematology Subcommittee 2 (HEM)
Program Officer
Mccarthy, Susan A
Project Start
1987-04-01
Project End
2001-03-31
Budget Start
1999-07-01
Budget End
2000-06-30
Support Year
12
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Wayne State University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Li, Xiaohua; Meng, Hong; Chen, Ben D (2009) Differentiation-Associated Expression of Conventional Protein Kinase C Isoforms in Primary Cultures of Bone Marrow Cells Induced by M-CSF and G-CSF. Am J Biomed Sci 1:47-55
Li, Xiaohua; Chen, Ben D (2009) Histone Deacetylase Inhibitor M344 Inhibits Cell Proliferation and Induces Apoptosis in Human THP-1 Leukemia Cells. Am J Biomed Sci 1:352-363
Chu, Arthur J; Chou, Ta-Hsu; Chen, Ben D (2004) Prevention of colorectal cancer using COX-2 inhibitors: basic science and clinical applications. Front Biosci 9:2697-713
Lin, Hong; Subramanian, Balanehru; Nakeff, Alex et al. (2002) XK469, a novel antitumor agent, inhibits signaling by the MEK/MAPK signaling pathway. Cancer Chemother Pharmacol 49:281-6
Lin, Hong; Liu, Xiang Y; Subramanian, Balanehru et al. (2002) Mitotic arrest induced by XK469, a novel antitumor agent, is correlated with the inhibition of cyclin B1 ubiquitination. Int J Cancer 97:121-8
Lin, Hong; Chen, Catheryne; Li, Xiaohua et al. (2002) Activation of the MEK/MAPK pathway is involved in bryostatin1-induced monocytic differenciation and up-regulation of X-linked inhibitor of apoptosis protein. Exp Cell Res 272:192-8
Lin, H; Chen, C; Chen, B D (2001) Resistance of bone marrow-derived macrophages to apoptosis is associated with the expression of X-linked inhibitor of apoptosis protein in primary cultures of bone marrow cells. Biochem J 353:299-306
Chen, C; Lin, H; Karanes, C et al. (2000) Human THP-1 monocytic leukemic cells induced to undergo monocytic differentiation by bryostatin 1 are refractory to proteasome inhibitor-induced apoptosis. Cancer Res 60:4377-85
Chen, C; Lin, H; Chen, B D (2000) Bcl-2 antibodies induce hemoglobin release by red blood cells loaded with in vitro translated Bcl-2 and its cleaved fragment. Biochem Biophys Res Commun 270:816-20
Lin, H; Zhang, X M; Chen, C et al. (2000) Apoptosis of Mo7e leukemia cells is associated with the cleavage of Bcl-2 into a shortened fragment that is not functional for heterodimerization with Bcl-2 and Bax. Exp Cell Res 261:180-6

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